The level of intelligibility attained by speakers with cleft palate reflects not only the ability to achieve adequate velopharyngeal closure but other complex variables as well. When closure is inadequate, performance is influenced by compensatory responses of the tongue, vocal folds, respiratory muscles and nasal valve. The purpose of the present study was to determine how a loss of velar resistance associated with velopharyngeal inadequacy affects speech pressures and airflow. The pressure-flow technique (Warren, 1979) was used to assess mean airflow rate, mean intraoral and nasal pressures and velopharyngeal orifice areas in 211 subjects diagnosed as having cleft palate or velopharyngeal inadequacy. The data revealed that resistance fell as velopharyngeal orifice area increased. Intraoral pressures also fell as resistance dropped while nasal pressures and airflow rate increased. These findings suggest that individuals with velar inadequacy and associated low velar resistance compensate by increasing airflow rate in an attempt to maintain adequate pressures for consonant sound production.
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http://dx.doi.org/10.1093/oxfordjournals.ejo.a035965 | DOI Listing |
Biotechnol Rep (Amst)
June 2024
Department of Bioinformatics, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620 024, India.
Novel anticancer drugs of natural origin have increased tremendously due to the resistance of multiple chemotherapeutic drugs in breast cancer therapy and their high toxicity with undesirable side effects. The study investigates the bioactivity of secondary metabolites derived from PSMS6 isolated from marine soil sediment in the Velar estuary, Parangepattai, Cuddalore district, Tamil Nadu, and India. Strains were isolated and antagonistic activity was screened using the agar well diffusion method.
View Article and Find Full Text PDFOrphanet J Rare Dis
April 2018
Center for Cleft Palate & Craniofacial Malformations, Tübingen University Hospital, Tübingen, Germany.
Background: Infants and children with syndromic craniosynostosis (SCS), such as Apert-, Crouzon- or Pfeiffer syndrome, are prone to sleep disordered breathing (SDB) including obstructive sleep apnea and upper airway resistance syndrome (OSAS, UARS), potentially leading to tracheostomy. We modified the Tübingen Palatal Plate (TPP), an oral appliance with a velar extension effectively treating airway obstruction in Robin sequence, by attaching a tube to its velar extension to bridge the narrow pharyngeal airway in SCS patients. Here, we evaluated this treatment concept.
View Article and Find Full Text PDFCleft Palate Craniofac J
October 2018
Department of Speech and Hearing Science, Ohio State University, Columbus, OH, USA.
Objective: To evaluate the feasibility/effectiveness of using magnetic resonance imaging (MRI) to document velopharyngeal (VP) structural changes induced by continuous positive airway pressure (CPAP) therapy.
Outcome Measures: Changes in velar length and thickness, levator veli palatini (LVP) length and thickness, velar volume, and intravelar muscular proportion along the course of CPAP therapy participation (Pre-CPAP, Post-CPAP, and withdrawal).
Results: Velar and LVP lengths remained nearly the same, with the median changes (Δ) less than 0.
Biomedica
December 2017
Laboratorio Nacional de Referencia de Micología, Instituto de Medicina Tropical "Pedro Kourí", La Habana, Cuba.
Introduction: The behavior of antifungal susceptibility of Aspergillus spp. in Cuba remains unknown. The antifungals recommended to treat aspergillosis are amphotericin B, itraconazole, voriconazole and echinocandins.
View Article and Find Full Text PDFTrop Anim Health Prod
December 2016
Veterinary Biological and Pharmacological Sciences Department, Comparative Anatomy Unit-URAC49, Hassan II Agronomy and Veterinary Institute, BP 6202, Rabat-Instituts, Morocco.
The tonsils, located around the pharyngeal cavity, constitute the first defence barrier against intruding microorganisms and antigens. The present work aimed to study the anatomical and histological aspects of camel tonsils in order to elucidate their role. The study was carried out on 12 camel heads fixed by infusion with 10 % neutral buffered formalin.
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