AI Article Synopsis
- The development of non-invasive magnetically guided magneto-electric nanocarriers (MENCs) enables targeted drug delivery across the blood-brain barrier to treat CNS diseases.
- The study demonstrated the effective delivery of ~20 nm MENCs at a dosage of 10 mg/kg in mice, showing a uniform distribution throughout the brain.
- Importantly, the MENCs were found to be non-toxic to major organs and did not affect overall organ function or neurobehavioral health.
Article Abstract
Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, across BBB in C57Bl/J mice. Delivered MENCs were uniformly distributed inside the brain, and were non-toxic to brain and other major organs, such as kidney, lung, liver, and spleen, and did not affect hepatic, kidney and neurobehavioral functioning.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855156 | PMC |
| http://dx.doi.org/10.1038/srep25309 | DOI Listing |
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