AI Article Synopsis
- The study investigates the significance of pretreatment metabolic tumor volume (MTV) in predicting outcomes for patients with piriform sinus carcinoma undergoing radiation therapy.
- A retrospective analysis of 100 patients revealed that those with high MTV have worse 5-year disease-free survival (DFS) rates compared to those with low MTV.
- MTV, along with nodal metastasis and chemotherapy regimen, were identified as independent factors influencing DFS, highlighting the importance of MTV in treatment planning.
Article Abstract
Background: The purpose of this study was to elucidate the prognostic significance of the pretreatment metabolic tumor volume (MTV) in patients with piriform sinus carcinoma treated by radiation-based therapy.
Methods: This retrospective study included 100 patients with piriform sinus carcinomas who had received treatment by radiation-based therapy. The MTV values were obtained from pretreatment positron emission tomography (PET). The association between clinical factors, including the MTV, and survival was analyzed.
Results: Kaplan-Meier estimates revealed the 5-year disease-free survival (DFS) rates were significantly poorer for patients with a high MTV compared to those with a low MTV. In the multivariate analysis, MTV (p < .001), nodal metastasis (p = .011), and applied chemotherapy regimen (p = .004) were found to be independent prognostic factors for DFS.
Conclusion: The locoregional MTV is a prognostic factor for DFS in patients with piriform sinus carcinoma treated by radiation-based therapy. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708-1716, 2016.
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| http://dx.doi.org/10.1002/hed.24488 | DOI Listing |
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