AI Article Synopsis
- The study focuses on identifying biomarkers for Amyotrophic lateral sclerosis (ALS), which could help with early detection and treatment.
- The researchers used SILAC to analyze proteins in ALS and normal human fibroblasts, identifying a total of 861 proteins.
- Among the 33 proteins that were differentially regulated, ApoB48 and Hsp20 were found to be downregulated, while Fibulin-1 was upregulated, suggesting their potential as new biomarkers and therapeutic targets for ALS.
Article Abstract
Aim: Amyotrophic lateral sclerosis (ALS) is a debilitating fatal neurodegenerative disorder. 90-95% of ALS cases are sporadic with no clear risk factors associated with the disease. Identification of biomarkers associated with ALS may lead to early detection and make it more amenable to therapeutic intervention.
Materials & Methods: SILAC was used to quantitatively analyze the proteomes of ALS and control human fibroblasts.
Results: Out of total of 861 proteins identified, 33 were found to be differentially regulated. ApoB48 and Hsp20 were downregulated, while Fibulin-1 was upregulated.
Conclusion: We report the differential regulation of these proteins in ALS fibroblasts, and their potential as novel biomarkers and possible drug targets for ALS.
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| http://dx.doi.org/10.2217/bmm-2016-0025 | DOI Listing |
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