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Adipokine Imbalance in the Pericardial Cavity of Cardiac and Vascular Disease Patients. | LitMetric

AI Article Synopsis

  • The study investigates the relationship between inflammatory and atherogenic hormones in the pericardial fluid and circulation of patients with cardiovascular disease, focusing on fat-related proteins.
  • The research found that while levels of leptin were similar in pericardial fluid and plasma, A-FABP levels were significantly higher and adiponectin levels were significantly lower in pericardial fluid compared to plasma.
  • The findings suggest that the abnormal levels of A-FABP and adiponectin in the pericardial fluid are likely influenced more by the heart itself than by the surrounding circulation or related fat tissue.

Article Abstract

Aim: Obesity and especially hypertrophy of epicardial adipose tissue accelerate coronary atherogenesis. We aimed at comparing levels of inflammatory and atherogenic hormones from adipose tissue in the pericardial fluid and circulation of cardiovascular disease patients.

Methods And Results: Venous plasma (P) and pericardial fluid (PF) were obtained from elective cardiothoracic surgery patients (n = 37). Concentrations of leptin, adipocyte fatty acid-binding protein (A-FABP) and adiponectin (APN) were determined by enzyme-linked immunosorbent assays (ELISA). The median concentration of leptin in PF (4.3 (interquartile range: 2.8-9.1) μg/L) was comparable to that in P (5.9 (2.2-11) μg/L) and these were significantly correlated to most of the same patient characteristics. The concentration of A-FABP was markedly higher (73 (28-124) versus 8.4 (5.2-14) μg/L) and that of APN was markedly lower (2.8 (1.7-4.2) versus 13 (7.2-19) mg/L) in PF compared to P. APN in PF was unlike in P not significantly related to age, body mass index, plasma triglycerides or coronary artery disease. PF levels of APN, but not A-FABP, were related to the size of paracardial adipocytes. PF levels of APN and A-FABP were not related to the immunoreactivity of paracardial adipocytes for these proteins.

Conclusion: In cardiac and vascular disease patients, PF is enriched in A-FABP and poor in APN. This adipokine microenvironment is more likely determined by the heart than by the circulation or paracardial adipose tissue.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854456PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154693PLOS

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