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Publication Analysis
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preexposure prophylaxis
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Background: Long-acting formulations of HIV pre-exposure prophylaxis (PrEP) appear particularly well suited to adolescents. We aimed to establish the safety, tolerability, and acceptability of long-acting injectable cabotegravir as PrEP in cisgender adolescent girls.
Methods: HPTN 084-01 is a single-arm, open-label, phase 2b trial conducted at three clinical research sites in South Africa, Uganda, and Zimbabwe.
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J Microbiol Immunol Infect
March 2025
School of Pharmacy, National Taiwan University College of Medicine, Taipei, Taiwan; The Metabolomics Core Laboratory, Center of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan; Department of Pharmacy, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:
Background/purpose(s): Data regarding the concentrations of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP) in the Asian population receiving pre-exposure prophylaxis (PrEP) for HIV with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) (TDF/FTC) are limited, and the associations between the frequency of TDF/FTC administration and drug concentration among people receiving on-demand PrEP remain unclear.
Methods: Fifty-seven participants receiving daily TDF/FTC and 113 participants receiving on-demand TDF/FTC were enrolled in this study. The concentrations of TFV-DP and FTC-TP were measured in dried blood spots using liquid chromatography‒mass spectrometry.
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Lancet
March 2025
Gilead Sciences, Foster City, CA, USA. Electronic address:
Background: Long-acting antiretrovirals can address barriers to HIV pre-exposure prophylaxis (PrEP), such as stigma and adherence. In two phase 3 trials, twice-yearly subcutaneous lenacapavir was safe and highly efficacious for PrEP in diverse populations. Furthering long-acting PrEP efforts, this study assessed the pharmacokinetics and safety of two once-yearly intramuscular lenacapavir formulations.
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Lancet
March 2025
CHIP, Centre of Excellence for Health, Immunity and Infections, Section 2100, Rigshospitalet, 2100 Copenhagen OE, Denmark; Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address:
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J Theor Biol
March 2025
Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, 98101, United States; organization=Stanford Prevention Research Center, organization=Department of Medicine, organization=Stanford University, city=Palo Alto, state=CA, postcode=94304, country=United States. Electronic address:
Pre-exposure prophylaxis (PrEP) is increasingly used to prevent the transmission of H.I.V.
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