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DNA Methylation Pattern of Gene Promoters of MB-COMT, DRD2, and NR3C1 in Turkish Patients Diagnosed with Schizophrenia.
Clin Psychopharmacol Neurosci
November 2022
Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Objective: We aim to evaluate the methylation status of membrane-bound catechol-O-methyltransferase () promotor, dopamine receptor D2 (), and nuclear receptor subfamily 3 group C member 1 () gene in pa- tients with SCZ by comparing healthy controls.
Methods: A sample of 110 patients with SCZ and 100 age- and sex-matched healthy volunteers was included in the study. The interview was started by filling out data forms that included sociodemographic and clinical information.
Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms.
Clin Epigenetics
May 2022
Genomic Medicine Research Group, Ulster University, Coleraine, Northern Ireland, UK.
Background: We previously showed that continued folic acid (FA) supplementation beyond the first trimester of pregnancy appears to have beneficial effects on neurocognitive performance in children followed for up to 11 years, but the biological mechanism for this effect has remained unclear. Using samples from our randomized controlled trial of folic acid supplementation in second and third trimester (FASSTT), where significant improvements in cognitive and psychosocial performance were demonstrated in children from mothers supplemented in pregnancy with 400 µg/day FA compared with placebo, we examined methylation patterns from cord blood (CB) using the EPIC array which covers approximately 850,000 cytosine-guanine (CG) sites across the genome. Genes showing significant differences were verified using pyrosequencing and mechanistic approaches used in vitro to determine effects on transcription.
View Article and Find Full Text PDFInvolvement of the Catecholamine Pathway in Glioblastoma Development.
Cells
March 2021
Institute of Laboratory Medicine, School of Medicine, University of Pécs, 7624 Pécs, Hungary.
Glioblastoma (GBM) is the most aggressive tumor of the central nervous system (CNS). The standard of care improves the overall survival of patients only by a few months. Explorations of new therapeutic targets related to molecular properties of the tumor are under way.
View Article and Find Full Text PDFDetection of altered methylation of MB-COMT promotor and DRD2 gene in cannabinoid or synthetic cannabinoid use disorder regarding gene variants and clinical parameters.
J Addict Dis
November 2021
Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
This study aims to investigate the association between cannabinoid use disorder (CUD) or synthetic cannabinoid use disorder (SCUD) and methylation status of MB-COMT (membrane-bound catechol-O-methyltransferase) promotor or DRD2 gene considering gene variants and clinical parameters. Based on the DSM-5 criteria, 218 CUD/SCUD patients' diagnoses were confirmed with a positive urine test, and a control group consisting of 102 participants without substance use disorders was included. Methylation-specific PCR was used to identify the methylation of the MB-COMT promotor and DRD2 gene.
View Article and Find Full Text PDFDNA-methylation of the dopamin receptor 2 gene is altered during alcohol withdrawal.
Eur Neuropsychopharmacol
November 2019
Center for Addiction Research (CARe), Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, 30625 Hannover, Germany; Molecular Neurosciences Laboratory, Department of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Germany. Electronic address:
The dopaminergic neurotransmission is known to be of crucial importance in addictive behavior. Epigenetic regulation like methylation of DNA influences the function of dopaminergic transmission. The present study investigated alterations of DNA methylation in the dopamine D2 receptor (DRD2)-gene in patients suffering from alcohol dependence.
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