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http://dx.doi.org/10.1016/j.nefro.2016.03.002 | DOI Listing |
medRxiv
December 2024
J. David Gladstone Institutes, San Francisco, 94158, California,USA.
Failure to rapidly diagnose tuberculosis disease (TB) and initiate treatment is a driving factor of TB as a leading cause of death in children. Current TB diagnostic assays have poor performance in children, and identifying novel non-sputum-based TB biomarkers to improve pediatric TB diagnosis is a global priority. We sought to develop a plasma biosignature for TB by probing the plasma proteome of 511 children stratified by TB diagnostic classification and HIV status from sites in four low- and middle-income countries, using high-throughput data-independent acquisition mass-spectrometry (DIA-PASEF-MS).
View Article and Find Full Text PDFmedRxiv
June 2024
3. Center for Tuberculosis, University of California, San Francisco, USA.
Background: Computer-aided detection (CAD) algorithms for automated chest X-ray (CXR) reading have been endorsed by the World Health Organization for tuberculosis (TB) triage, but independent, multi-country assessment and comparison of current products are needed to guide implementation.
Methods: We conducted a head-to-head evaluation of five CAD algorithms for TB triage across seven countries. We included CXRs from adults who presented to outpatient facilities with at least two weeks of cough in India, Madagascar, the Philippines, South Africa, Tanzania, Uganda, and Vietnam.
The sputum colour in patients with severe pneumonia needs to be considered during diagnosis.
View Article and Find Full Text PDFBMJ Case Rep
January 2024
Robert Wood Johnson Health System, West Orange, New Jersey, USA.
Bacterial pneumonia causes significant morbidity and mortality especially in elderly and immunocompromised hosts. Achromobacter xylosoxidans denitrificans pneumonia is very rarely reported. However, the reported cases have been in patients who are either immunocompromised or have bronchiectasis.
View Article and Find Full Text PDFThorax
March 2024
Uganda Tuberculosis Implementation Research Consortium, Walimu, Kampala, Uganda.
Background: Systematic screening is a potential tool for reducing the prevalence of tuberculosis (TB) and counteracting COVID-19-related disruptions in care. Repeated community-wide screening can also measure changes in the prevalence of TB over time.
Methods: We conducted serial, cross-sectional TB case finding campaigns in one community in Kampala, Uganda, in 2019 and 2021.
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