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Vaginal power morcellation using a contained bag system: a novel surgical technique.
Facts Views Vis Obgyn
December 2024
Background: To decrease the risk of unsuspected malignancies disseminating, several studies have shown the safety of using a containment bag to limit tissue dissemination during manual or power morcellation. Furthermore, in 2020, the FDA recommended performing laparoscopic power morcellation for myomectomy or hysterectomy only within a tissue containment system.
Objective: To show step-by-step a new surgical technique using vaginal power morcellation within an endoscopic pouch without adding or extending other incisions.
Molecular, Histological, and Functional Changes in Acta1-MCM;FLExDUX4/+ Mice.
Int J Mol Sci
October 2024
NIHR Biomedical Research Centre, University College London, Great Ormond Street Institute of Child Health and Great Ormond Street Hospital NHS Trust, London WC1N 1EH, UK.
Article Synopsis
- DUX4 is the main gene linked to facioscapulohumeral dystrophy (FSHD), with effective mouse models, such as ACTA1-MCM/FLExDUX4, being used for research.
- The study focused on observing muscle changes in tibialis anterior and quadriceps at various stages, confirming the presence of progressive muscular dystrophy and identifying issues related to tamoxifen use and gene selection for DUX4 assessment.
- A new functional test was created to assess muscle strength, which revealed that DUX4 expression leads to weaker muscles with lower initial force but maintained power and endurance, suggesting potential applications for this model in human clinical evaluations.
Aberrant right subclavian artery stenting and embolisation for button battery-induced recurrent arterio-oesophageal fistula.
Cardiol Young
October 2024
CHU de Lille, Paediatric Cardiology, Lille, Hauts-de-France, France.
A young child, who had a previously unsuspected aberrant right subclavian retro-oesophageal artery, swallowed a button battery complicated with recurrent life-threatening bleeding, and survived after repeated percutaneous treatment as a bridge to surgery.
View Article and Find Full Text PDFGenomics Reveals Complex Population History and Unexpected Diversity of Eurasian Otters (Lutra lutra) in Britain Relative to Genetic Methods.
Mol Biol Evol
November 2023
School of Biosciences, Cardiff University, Cardiff, UK.
Conservation genetic analyses of many endangered species have been based on genotyping of microsatellite loci and sequencing of short fragments of mtDNA. The increase in power and resolution afforded by whole genome approaches may challenge conclusions made on limited numbers of loci and maternally inherited haploid markers. Here, we provide a matched comparison of whole genome sequencing versus microsatellite and control region (CR) genotyping for Eurasian otters (Lutra lutra).
View Article and Find Full Text PDFHigh-Dimensional Mediation Analysis: A New Method Applied to Maternal Smoking, Placental DNA Methylation, and Birth Outcomes.
Environ Health Perspect
April 2023
Université Grenoble-Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, Grenoble, France.
Article Synopsis
- High-dimensional mediation analysis (HDMA) assesses multiple mediators to understand environmental impacts on health, but no universally accepted methods exist for optimal analysis.
- The researchers developed a new method called HDMAX2 to evaluate how placental DNA methylation mediates the effects of maternal smoking on gestational age and birth weight.
- HDMAX2 showed increased statistical power compared to existing methods, identifying new aggregated mediator regions (AMRs) linked to lower birth weight and providing a deeper understanding of the mediation pathways.
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