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Case report: Adult case of A20 haploinsufficiency suspected as neuro-Behçet disease.
Front Immunol
January 2025
Department of Rheumatology & Allergology, Japanese Red Cross Medical Center, Tokyo, Japan.
Patients with A20 haploinsufficiency (HA20) presenting with central nervous system (CNS) symptoms are rare, and available reports are limited. Here, we describe a patient with HA20, previously followed up as Behçet disease, who presented with CNS symptoms in adulthood. A 38-year-old Japanese male who had been followed up for incomplete Behçet disease at another hospital since 28 years of age presented to our hospital with acute-onset diplopia and persistent hiccups that were severe enough to cause vomiting.
View Article and Find Full Text PDFSevere phlebitis and cutaneous necrosis following peripheral administration of high-concentration potassium chloride: A case report and vascular access management implications.
Sci Prog
January 2025
Department of Hepatobiliary Surgery, Liaoning Cancer Hospital & Institute, Cancer Hospital of China Medical University, Shenyang, China.
Electrolyte imbalance management is crucial in diverse clinical scenarios, with intravenous potassium repletion often required. High-concentration infusions can pose severe complications if extravasation occurs, leading to phlebitis, local tissue damage, or in severe cases, cutaneous necrosis. This risk is elevated in geriatric patients due to factors like reduced tissue elasticity and sensitivity.
View Article and Find Full Text PDFIntegrated analysis of genetic, proteinic, and metabolomic alterations in Behcet's disease.
Sci Rep
January 2025
Department of Ophthalmology, Bishan hospital of Chongqing medical university, Bishan Hospital of Chongqing, Chongqing, China, 402760.
Numerous studies have investigated the alterations of genes, proteins, and metabolites in Behcet's disease (BD). By far, little is known about the depiction of panoramic changes underlying this disease. This study purposed to assess the consistently dysregulated genes, proteins, and metabolites in BD across publications using the vote-counting approach.
View Article and Find Full Text PDFScreening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome.
BMC Vet Res
January 2025
Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, Frankfurter Strasse 112, D-35392, Giessen, Germany.
Background: The recently identified swine inflammation and necrosis syndrome (SINS) affects tail, ears, teats, coronary bands, claws and heels of affected individuals. The primarily endogenous syndrome is based on vasculitis, thrombosis, and intimal proliferation, involving defence cells, interleukins, chemokines, and acute phase proteins and accompanied by alterations in clinical chemistry, metabolome, and liver transcriptome. The complexity of metabolic alterations and the influence of the boar led to hypothesize a polygenic architecture of SINS.
View Article and Find Full Text PDFManagement of a Left Anterior Descending Artery Aneurysm in Behçet's Disease: A Case Report.
Mod Rheumatol Case Rep
January 2025
Department of Internal Medicine, King Faisal Specialist Hospital & research center, Jeddah, Saudi Arabia.
Behçet's disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology that affects blood vessels of all sizes, potentially leading to severe complications such as coronary artery aneurysms. This report describes the case of a 33-year-old woman with BD who presented with recurrent chest pain. Imaging revealed a large saccular aneurysm in the left anterior descending artery.
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