Background: HERG1 potassium channel plays a critical role in the cell proliferation.
Methods: HERG1 protein expression was analyzed by immunohistochemistry (IHC) in 62 patients with oral leukoplakias and 100 patients with oral squamous cell carcinomas (OSCC). HERG1 mRNA levels were assessed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in 22 patients with primary head and neck squamous cell carcinoma (HNSCC).
Results: Statistically significant associations were found between HERG1 expression and tobacco consumption, disease stage, tumor differentiation, tumor recurrence, and reduced survival. There was no association between HERG1 expression and the risk of progression from oral leukoplakia to OSCC. In addition, a high proportion of tumors (80%) showed increased HERG1 mRNA levels compared to normal mucosa from nononcologic patients.
Conclusion: Aberrant HERG1 expression increases as oral tumorigenesis progresses from oral hyperplasia to OSCC. Increased HERG1 mRNA levels were also frequently detected in OSCC and other HNSCC subsites. HERG1 expression emerges as a clinically relevant feature during tumor progression and a potential poor prognostic biomarker for OSCC. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708-1716, 2016.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hed.24493 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Targeting the hERG1 and β1 integrin complex for cancer treatment.
Expert Opin Ther Targets
March 2024
Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Firenze, Italy.
Introduction: Despite great advances, novel therapeutic targets and strategies are still needed, in particular for some carcinomas in the metastatic stage (breast cancer, colorectal cancer, pancreatic ductal adenocarcinoma and the clear cell renal carcinoma). Ion channels may be considered good cancer biomarkers and targets for antineoplastic therapy. These concepts are particularly relevant considering the hERG1 potassium channel as a novel target for antineoplastic therapy.
View Article and Find Full Text PDFIntegrins regulate hERG1 dynamics by girdin-dependent Gαi3: signaling and modeling in cancer cells.
Life Sci Alliance
January 2024
Department of Experimental and Clinical Medicine, Section of Internal Medicine, University of Florence, Florence, Italy
The hERG1 potassium channel is aberrantly over expressed in tumors and regulates the cancer cell response to integrin-dependent adhesion. We unravel a novel signaling pathway by which integrin engagement by the ECM protein fibronectin promotes hERG1 translocation to the plasma membrane and its association with β1 integrins, by activating girdin-dependent Gαi3 proteins and protein kinase B (Akt). By sequestering hERG1, β1 integrins make it avoid Rab5-mediated endocytosis, where unbound channels are degraded.
View Article and Find Full Text PDFAn Overview of Current Biomarkers, the Therapeutic Implications, and the Emerging Role of hERG1 Expression in Gastric Cancer: A Literature Review.
Cureus
October 2023
Internal Medicine, Countess of Chester Hospital NHS Foundation Trust, Chester, GBR.
Gastric cancer remains one of the most commonly diagnosed cancers in the world. It carries a high mortality rate, with cases being more prevalent in the developing world, and has been linked to diet and infection. It is a highly heterogeneous disease, with most cases being of a sporadic nature.
View Article and Find Full Text PDFPairwise biosynthesis of ion channels stabilizes excitability and mitigates arrhythmias.
Proc Natl Acad Sci U S A
October 2023
Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705.
Coordinated expression of ion channels is crucial for cardiac rhythms, neural signaling, and cell cycle progression. Perturbation of this balance results in many disorders including cardiac arrhythmias. Prior work revealed association of mRNAs encoding cardiac Na1.
View Article and Find Full Text PDFencodes a nuclear-targeted polypeptide that mediates hERG1 channel gating and expression.
Proc Natl Acad Sci U S A
January 2023
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109.
encodes hERG1, the voltage-gated potassium channel that conducts the rapid delayed rectifier potassium current (I) in human cardiac tissue. hERG1 is one of the first channels expressed during early cardiac development, and its dysfunction is associated with intrauterine fetal death, sudden infant death syndrome, cardiac arrhythmia, and sudden cardiac death. Here, we identified a hERG1 polypeptide (hERG1) that is targeted to the nuclei of immature cardiac cells, including human stem cell-derived cardiomyocytes (hiPSC-CMs) and neonatal rat cardiomyocytes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!