AI Article Synopsis
- Venezuelan equine encephalitis virus (VEEV) is a highly infectious virus recognized as a potential bio-terrorism threat, and there is currently no effective licensed vaccine available.
- Researchers inactivated an attenuated strain of VEEV using a chemical called 1,5-iodonaphthyl azide (INA) and tested its effectiveness against a virulent form of the virus.
- The study found that intramuscular vaccination with the INA-inactivated version (INA-iV3526) resulted in complete protection from the aerosolized virulent VEEV, indicating its potential as a viable vaccine candidate.
Article Abstract
Venezuelan equine encephalitis virus (VEEV) is a New World alphavirus. VEEV is highly infectious in aerosolized form and has been identified as a bio-terrorism agent. There is no licensed vaccine for prophylaxis against VEEV. The current IND vaccine is poorly immunogenic and does not protect against an aerosol challenge with virulent VEEV. We have previously shown that VEEV inactivated by 1,5-iodonaphthyl azide (INA) protects against footpad challenge with virulent VEEV. In this study, we inactivated an attenuated strain of VEEV, V3526, with INA and evaluated its protective efficacy against aerosol challenge with wild type VEEV. We demonstrated that among three routes of immunization, intramuscular immunization with INA-inactivate V3526 (INA-iV3526) provided complete protection against aerosol challenge with virulent VEEV. Our data suggests that INA-iV3526 can be explored further for development as an effective vaccine candidate against aerosol challenge of virulent VEEV.
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| http://dx.doi.org/10.1016/j.vaccine.2016.04.049 | DOI Listing |
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