AI Article Synopsis
- The study examined the link between serum vitamin D levels, vitamin D receptor (VDR) gene variations, and the likelihood of achieving sustained virological response (SVR) in chronic hepatitis C (CHC) patients.
- Involving 250 participants divided into three groups, it measured vitamin D levels and identified specific VDR polymorphisms using blood samples and genetic testing.
- Results indicated that patients who did not respond to treatment had lower vitamin D levels, and specific VDR polymorphisms (FokI and TaqI) were associated with successful treatment outcomes.
Article Abstract
Objective: The aim of this study was to find an association between serum concentration of vitamin D and vitamin D receptor (VDR) polymorphisms to achieve a sustained virological response (SVR).
Methods: We conducted a case-control study in which 250 participants were recruited and divided into three groups (100 chronic hepatitis C [CHC] patients who achieved SVR, 100 CHC patients who did not achieve SVR and 50 apparently healthy individuals as controls). Blood samples were collected to measure serum vitamin D concentration, and four VDR polymorphisms (FokI, ApaI, TaqI, and BsmI) were detected using polymerase chain reaction-restriction fragment length polymorphism.
Results: Non-responders were found to have significantly low vitamin D concentration compared with responders and control groups. Concerning VDR polymorphisms, both FokI and TaqI polymorphisms were associated with successful treatment.
Conclusion: Vitamin D concentration, FokI, and TaqI may be considered as the predictors for the response of CHC patients to a combination therapy of pegylated interferon and ribavirin.
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| http://dx.doi.org/10.1111/1751-2980.12353 | DOI Listing |
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