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Effect of mutation of secG gene in drug resistance and physiological and biochemical activities of Xanthomonas oryzae pv. oryzae.
Pest Manag Sci
November 2024
School of Tropical Agriculture and Forestry, Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests (Hainan University), Ministry of Education, Haikou, China.
Background: Bacterial leaf blight caused by the bacterium Xanthomonas oryzae pv. oryzae has a substantial effect on the yield of rice crops. The secretory (Sec) pathway, essential for efflux transport in bacteria, remains insufficiently studied in X.
View Article and Find Full Text PDFDoxophylline, a Non-Selective Phosphodiesterase Inhibitor, Protects Against Chronic Fatigue-Induced Neurobehavioral, Biochemical, and Mitochondrial Alterations.
Neurochem Res
November 2024
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India.
Chronic fatigue stress (CFS) is a multisystem disorder which exhibits multiple signs of neurological complications like brain fog, cognitive deficits and oxidative stress with no specific treatment. Doxophylline, a non-selective phosphodiesterase inhibitor (PDEI), has anti-inflammatory properties with enhanced blood-brain barrier penetration and tissue specificity. We have evaluated the neuroprotective potential of doxophylline in a murine model of forced swim test (FST) induced CFS and in HO (hydrogen peroxide) induced oxidative stress in PC12 cells.
View Article and Find Full Text PDFEffects of E2 on the IDO1-mediated metabolic KYN pathway in OVX female mice.
J Cell Mol Med
October 2024
Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
The aim of this study was to investigate the role of 17β-estradiol (E2)-mediated oestrogen receptor (ER) in modulating the depressive-like behaviours of ovariectomy (OVX) mice and the associated mechanisms. E2 was administrated in OVX mice. The behaviour and physiological changes of OVX mice including immobility time in tail suspension test (TST) and forced swimming test (FST), levels of serum E2, inflammatory mediators, oxidative stress factors, indoleamine2,3-dioxygenase 1 (IDO1) and the neurotransmitters mediated by IDO1 activation were then recorded.
View Article and Find Full Text PDFAssessing the therapeutic potential of KK14 peptide derived from Cyprinus Carpio in reducing intercellular ROS levels in oxidative Stress-Induced In vivo zebrafish larvae model: An integrated bioinformatics, antioxidant, and neuroprotective analysis.
J Biochem Mol Toxicol
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Department of Medical Biotechnology and Integrative Physiology, Institute of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, India.
HO is a significant reactive oxygen species (ROS) that hinders redox-mediated processes and contributes to oxidative stress and neurodegenerative disorders. Oxidative stress causes impairment of cell macromolecules, which results in cell dysfunction and neurodegeneration. Alzheimer's disease and other neurodegenerative diseases are serious conditions linked to oxidative stress.
View Article and Find Full Text PDFApelin/APJ signaling in IGF-1-induced acute mitochondrial and antioxidant effects in spontaneously hypertensive rat myocardium.
J Physiol Biochem
November 2024
Centro de Investigaciones Cardiovasculares "Horacio E. Cingolani" - Facultad de Ciencias Médicas, UNLP - CONICET, La Plata, Buenos Aires, Argentina.
IGF-1 and apelin are released in response to exercise training with beneficial effects. Previously we demonstrated that a swimming routine is effective to convert pathological into physiological cardiac hypertrophy, and that IGF-1 improves contractility and the redox state, in spontaneously hypertensive rats (SHR). Now, we hypothesize that the apelinergic pathway is involved in the cardioprotective effects of IGF-1 in the SHR.
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