Structural features of the endothelium interaction with the blood cellular elements during atherosclerotic processes of varying severity in the coronary arteries have been analyzed from the data of early sections and coronary artery biopsy specimens. The status of the endothelium has been uniform in macroscopically unchanged sites irrespective of the coronary atherosclerosis severity. A stable characteristic symptom of the initial stages of atherogenesis is the formation of crater-like defects and monocyte adhesion. Scanning electron microscopy has shown for the first time the presence of echinocytes in the blood of coronary patients and adhesion of these cells at the site of the endothelial monolayer destruction. The formation of microthrombi at the site of endothelial destruction is not a stable symptom of the initial stages of atherogenesis. Endothelial destruction and regeneration, aided by the platelets, can be observed at all stages of atherogenesis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Atherosclerosis (AS) is a major cause of cardiovascular disease. In particular, the unpredictable rupture of vulnerable atherosclerotic plaques (VASPs) can cause serious cardiovascular events such as myocardial infarction, stroke, and even sudden death. Therefore, early evaluation of the vulnerability of atherosclerotic plaques is of great importance.
View Article and Find Full Text PDFIdentifying Biomarkers for Atherosclerosis via Gene Expression and Biological Networking.
Curr Cardiol Rev
January 2025
School of Paramedics and Allied Health Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha, India.
Background: Atherosclerosis is a chronic disease caused by the accumulation of lipids, inflammatory cells, and fibrous elements in arterial walls, leading to plaque formation and cardiovascular conditions like coronary artery disease, stroke, and peripheral arterial disease. Factors like hyperlipidemia, hypertension, smoking, and diabetes contribute to its development. Diagnosis relies on imaging and biomarkers, while management includes lifestyle modifications, pharmacotherapy, and surgical interventions.
View Article and Find Full Text PDFEndogenous multiple modified LDL (mLDL) and the renin-angiotensin system play a significant role in the development of atherosclerosis. It has been found that by behavioral and hemodynamic parameters the physiological activity of angiotensin II (Ang II) in combination with mLDL is considerably modified due to weakening of its diuretic effect and the inversion of hypertensive and tachyarrhythmic effects. Atherosclerosis is a long-term pathological process, so a single administration of artificially synthesized Ang I-mLDL complexes can be considered a model of the first contact of the body with pathogenic factors.
View Article and Find Full Text PDFLetter to the editor: Lipoproteins and lipoprotein lipid composition are associated with stages of dysglycemia and subclinical coronary atherosclerosis.
Int J Cardiol
December 2024
Department of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China. Electronic address:
Clinical profiles and their interaction of concurrent metabolic associated steatotic liver disease and hepatitis B virus infection.
World J Hepatol
December 2024
Department of Internal Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan.
Background: A new nomenclature of metabolic associated steatotic liver disease (MASLD) was proposed in 2023, thus expanding the diagnostic name of "MASLD combined with other etiologies".
Aim: To investigate the clinical profiles of patients with concurrent MASLD and chronic hepatitis B virus (HBV) infection.
Methods: This study included participants from the Taiwan Bio-bank.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!