AI Article Synopsis
- The study examined the link between specific chromosome types (dicentric chromosomes and acentric fragments) and cancer risk in individuals exposed to ionizing radiation (IR).
- Researchers analyzed data from 3,574 individuals, comparing those exposed to IR with a control group over an average of 8 years.
- Findings indicated that both acentric fragments and dicentric chromosomes significantly increased cancer risk, suggesting that acentric fragments may serve as a promising biomarker for detecting IR exposure and related cancer risks.
Article Abstract
Background/aim: Biomonitoring is currently applied in the estimation of health risks after overexposure to ionizing radiation (IR). The aim of this study was to compare the association of dicentric chromosomes and acentric fragments (AF) with cancer risk in subjects exposed to IR, as well as in control subjects.
Materials And Methods: The study was performed on 3,574 subjects (2,030 subjects exposed to IR and 1,544 control subjects). The mean follow-up period was 8 years.
Results: In subjects reporting exposure to IR, the presence of AFs and dicentric chromosomes was associated with a significant increase in cancer risk, hazard ratio (HR)=1.78 (95% confidence interval (CI)=1.01-3.13) and HR=1.73 (95% CI=1.03-2.90), respectively.
Conclusion: AFs are associated with cancer risk and have a similar sensitivity to dicentric chromosomes in subjects exposed to IR. Because automated AF scoring can be easily introduced using fast flow cytometry combined with the pan-centromere staining, this biomarker may hold promise as a potential sensitive biomarker of exposure to IR and cancer risk.
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