AI Article Synopsis
- A multifunctional Fe3O4/Au cluster/shell nanocomposite was developed for a theranostic strategy, enabling simultaneous detection and treatment of prostate cancer.
- It successfully detected free prostate specific antigen (free-PSA) at extremely low concentrations (1 ng/mL), with a limit of detection at 0.75 ng/mL.
- The strategy also facilitated MRI for tumor visualization and magnetic hyperthermia, which effectively killed tumor cells, showcasing its potential benefits in cancer therapy.
Article Abstract
A surface-enhanced Raman scattering (SERS)-assisted theranostic strategy was designed based on a synthesized multifunctional Fe3O4/Au cluster/shell nanocomposite. This theranostic strategy was used for free prostate specific antigen (free-PSA) detection, magnetic resonance imaging (MRI), and magnetic hyperthermia. The lowest protein concentration detected was 1ngmL(-1), and the limit of detection (LOD) of the calculated PSA was 0.75ngmL(-1). Then, MRI was carried out to visualize the tumor cell. Lastly, magnetic hyperthermia was employed and revealed a favorable killing effect for the tumor cells. Thus, this SERS-assisted strategy based on a Fe3O4/Au cluster/shell nanocomposite showed great advantages in theranostic treatment.
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| http://dx.doi.org/10.1016/j.msec.2016.03.090 | DOI Listing |
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