AI Article Synopsis
- A new iridium-catalyzed reaction creates 2H-azirines from isoxazol-5(4H)-ones without using phosphine.
- The process involves decarboxylation and ring contraction, offering a more efficient method for synthesizing these compounds.
- This approach is environmentally friendly and could serve as an alternative to traditional synthesis methods.
Article Abstract
A phosphine-free iridium-catalyzed reaction of isoxazol-5(4H)-ones (isoxazolones) has been developed, and affords 2H-azirines through decarboxylation and ring contraction. This method provides an efficient and environmentally benign protocol which could replace the conventional approaches used to synthesize 2H-azirines.
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| http://dx.doi.org/10.1002/anie.201602241 | DOI Listing |
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