AI Article Synopsis
- Klotho protein acts as a β-glucuronidase, breaking down steroid β-glucuronides, and exists in both membrane-bound and circulating forms.
- It is known as an antiaging gene and has multiple functions that may influence various chronic and degenerative diseases tied to inflammation.
- Klotho helps suppress the activation of NFκB, a key player in inflammatory responses, potentially affecting the underlying mechanisms of related health issues.
Article Abstract
Klotho protein is a β-glucuronidase capable of hydrolyzing steroid β-glucuronides. Two molecules are produced by the Klotho gene, a membrane bound form and a circulating form. This protein is recognized as an antiaging gene with pleiotropic functions. The activation of cellular systems is associated with the pathogenesis of several chronic and degenerative diseases associated with an inflammatory state. Inflammation is characterized by an activation of NFκB. Klotho suppresses nuclear factor NFκB activation and the subsequent transcription of proinflammatory genes. This review focuses on the current understanding of Klotho protein function and its relationship with NFκB regulation, emphasizing its potential involvement in the pathophysiologic process.
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| http://dx.doi.org/10.1016/bs.vh.2016.02.005 | DOI Listing |
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