AI Article Synopsis
- - The study discusses a rare case of a 15-year-old girl diagnosed with primary mediastinal large B-cell lymphoma (PMLBCL), which is known for its aggressiveness and specific characteristics.
- - Genetic testing revealed "double-hit" (DH) abnormalities involving the MYC and BCL6 genes, expanding the understanding of how DH events can occur in PMLBCL, where such associations were previously unreported.
- - The findings highlight the importance of cytogenetic testing for DH abnormalities in aggressive large B-cell lymphomas to improve diagnosis and treatment options.
Article Abstract
Objectives: Primary mediastinal large B-cell lymphomas (PMLBCLs) are aggressive lymphomas with characteristic clinical, morphologic, and immunophenotypic features. "Double-hit" (DH) lymphomas are B-cell neoplasms characterized by a translocation involving MYC and either BCL2 or BCL6 In the indexed literature, there are no reported cases of PMLBCL associated with DH or triple-hit events.
Methods: Herein, we present a case of a 15-year-old girl with PMLBCL who had typical clinical, morphologic, and immunophenotypic features.
Results: Fluorescent in situ hybridization studies showed rearrangements involving MYC and BCL6 We also excluded the possibility of a reciprocal t(3;8) (3q27;8q24) BCL6/MYC translocation.
Conclusions: This case expands the current spectrum of lymphomas subtypes in which DH can be found and supports the rationale for cytogenetic testing for DH abnormalities in all cases of aggressive large B-cell lymphomas regardless of subtype.
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| http://dx.doi.org/10.1093/ajcp/aqw018 | DOI Listing |
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