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An illustrated description of a modified collagenase Clostridium histolyticum protocol for Peyronie's disease.
J Sex Med
December 2024
Department of Life Sciences, Brigham Young University, Provo, UT, 84602, United States.
Background: Our team recently published outcomes of a novel technique for the administration of Collagenase Clostridium histolyticum (CCH), which resulted in improved curvature outcomes and reduced number of CCH injections required.
Aim: To provide a detailed and illustrated description of our CCH-administration technique.
Methods: A descriptive summary is provided of the technique, including drug administration, protocol modifications, and post-treatment protocols.
Oral Capsule FMT Combined With Bezlotoxumab Is a Successful Rescue Protocol Following Failure of FMT Alone in the Treatment of Recurrent C. difficile Infection.
J Clin Gastroenterol
November 2024
Division of Gastroenterology, Department of Medicine, University of Minnesota, Minneapolis, MN.
Article Synopsis
- The study aimed to assess the effectiveness of adding bezlotoxumab to repeat fecal microbiota transplantation (FMT) for patients with recurrent Clostridioides difficile infections after a previous unsuccessful FMT.
- It was found that combining bezlotoxumab with a second FMT significantly increased the cure rate from 48% to 89%.
- The research highlights the importance of understanding how bezlotoxumab and FMT work together and suggests that similar strategies could apply to other treatments for preventing C. difficile infection recurrence.
Structural insight into recognition of Clostridioides difficile toxin A by novel neutralizing nanobodies targeting QTIN-like motifs within its receptor-binding domain.
Int J Biol Macromol
December 2024
Gamaleya Research Center for Epidemiology and Microbiology, Russian Ministry of Public Health, Moscow 123098, Russia. Electronic address:
Clostridioides difficile causes a large proportion of nosocomial colon infections by producing toxins TcdA and TcdB as key virulence factors. TcdA and TcdB have analogous domain structures with a receptor-binding domain containing C-terminal combined repetitive oligopeptides (CROPs), an attractive target for the development of therapeutic antibodies. Here, we identify and characterize two potent neutralizing single-domain camelid anti-CROPsA antibodies, C4.
View Article and Find Full Text PDFClostridium Septicum: Cause of Gas Gangrene in the Upper Extremity Leading to Proximal Trans-Humeral Amputation, A Review of Clostridium septicum.
J Orthop Case Rep
November 2024
Department of Orthopaedic Surgery, Philadelphia Hand Surgeon PLLC, Lankenau Medical Center, Wynnewood, Pennsylvania.
Introduction: Gas gangrene is a rare, often lethal infection of soft tissue that is commonly associated with the Clostridial species due to penetrating injuries. Case reports of spontaneous atraumatic gas gangrene due to the Clostridium septicum species are exceedingly rare. Atraumatic C.
View Article and Find Full Text PDF'Does this fecal microbiota transplant work?' Quality assurance of capsule based fecal microbiota transplant production.
Scand J Gastroenterol
November 2024
Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
Background: Fecal Microbiota Transplant (FMT) is an effective treatment for recurring Clostridioides Difficile Infections (rCDI). FMT administered oral capsules (caFMT) offers several practical advantages to conventional liquid FMT. We began using caFMT in 2021 imported from an external institution.
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