AI Article Synopsis

  • - The study aimed to evaluate whether having multiple sclerosis (MS) affects pregnancy outcomes by comparing a group of pregnant women with MS to a control group of healthy pregnant women over a 10-year period.
  • - Results showed that most pregnancy complications, like preterm delivery and fetal growth issues, were similar between the two groups; however, women with MS experienced higher rates of urinary tract infections and lower breastfeeding rates.
  • - The findings concluded that while MS did not significantly impact overall maternal and perinatal outcomes, it was associated with increased risks of some specific issues during and after pregnancy.

Article Abstract

Objective: To assess whether maternal multiple sclerosis (MS) is associated with adverse pregnancy outcomes by determining the clinical course of disease during pregnancy and postpartum throughout a 10-year-period in a single tertiary center.

Methods: We conducted a case-control study that included pregnancies with a definitive diagnosis of MS (n=43), matched with 100 healthy pregnant women with similar characteristics. Maternal and perinatal data were retrieved from hospital files. Groups were compared with the Mann-Whitney and χ2 tests. Logistic regression models were constructed to determine independent effects.

Results: Maternal demographic and baseline laboratory data were similar across the groups. Rates of preterm delivery, fetal growth restriction, preeclampsia, gestational diabetes, stillbirth, cesarean delivery, congenital malformation, and 5-min Apgar score were comparable (P>0.05 for all). General anesthesia during cesarean delivery (96% vs. 39%, P=0.002), urinary tract infection (UTI) (12% vs. 3%, P=0.04), low 1-min Apgar score (21% vs. 9%, P=0.04), and nonbreastfeeding (33% vs. 2%, P=0.001) were more frequent in women with MS. The low 1-min Apgar score and breastfeeding rates were independent of general anesthesia and UTI in regression models.

Conclusion: MS during pregnancy was not associated with adverse maternal and perinatal outcomes except UTI, low 1-min Apgar scores, and decreased breastfeeding rates.

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Source
http://dx.doi.org/10.1515/jpm-2016-0060DOI Listing

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