Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fsigen.2016.04.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
RNA Diagnostics and Therapeutics: A Comprehensive Review.
RNA Biol
January 2025
Department of Biotechnology, Manipal Institute of Technology (MIT), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India.
RNA-focused therapy and diagnostics have been making waves in molecular biology due to the advantages RNA has over DNA; for instance, the ability of RNA to target nearly any genetic component in the cell is a big step in treating disorders. Moreover, RNA-based diagnosis of diseases is only becoming increasingly popular, especially after the COVID-19 pandemic, which brought up the need for cost-effective and efficient diagnosing kits for the vast majority. RNA-based techniques also have close to no risk of genotoxicity and can efficiently target undruggable regions of the cell.
View Article and Find Full Text PDFAdvancing crop improvement through GWAS and beyond in mung bean.
Front Plant Sci
December 2024
Nuclear Institute for Agriculture and Biology College, Pakistan Institute of Engineering and Applied Science (NIAB-C, PIEAS), Faisalabad, Pakistan.
Accessing the underlying genetics of complex traits, especially in small grain pulses is an important breeding objective for crop improvement. Genome-wide association studies (GWAS) analyze thousands of genetic variants across several genomes to identify links with specific traits. This approach has discovered many strong associations between genes and traits, and the number of associated variants is expected to continue to increase as GWAS sample sizes increase.
View Article and Find Full Text PDFGenetic counselling in the era of next generation sequencing.
An Pediatr (Engl Ed)
December 2024
Grupo de investigación en enfermedades raras, Laboratorio de (epi)genética molecular, Instituto de Investigación Sanitaria Bioaraba, Hospital Universitario Araba, Vitoria-Gasteiz, Spain. Electronic address:
Advances in next-generation sequencing (NGS) technologies have made the detection of the molecular causes of paediatric diseases increasingly affordable, accessible and rapid. While exome sequencing and genome sequencing were until recently only available for research, they are now used in health care practice. The clinical application of NGS has raised many challenges in genetic counselling for families in terms of the interpretation of test results and incidental findings, as well as technical limitations in the event of inconclusive results.
View Article and Find Full Text PDFThe Prognostic Quality of Risk Prediction Models to Assess the Individual Breast Cancer Risk in Women: An Overview of Reviews.
Breast J
January 2025
HTA Austria-Austrian Institute for Health Technology Assessment (AIHTA) GmbH, Garnisongasse 7/21, Vienna 1090, Austria.
Purpose: Breast cancer is the most common cancer among women globally, with an incidence of approximately two million cases in 2018. Organised age-based breast cancer screening programs were established worldwide to detect breast cancer earlier and to reduce mortality. Currently, there is substantial anticipation regarding risk-adjusted screening programs, considering various risk factors in addition to age.
View Article and Find Full Text PDFCardiovascular diseases (CVDs) constitute an important cause of morbidity and mortality globally, and India is no exception to this trend. With the ongoing aging of the population in India, there is a notable surge in the prevalence and impact of CVDs among older adults. This review is aimed at providing a comprehensive overview of the current knowledge concerning the prevalence, risk factors, and management of CVDs in the context of Indian older adults.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!