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Crocin protects human embryonic kidney cells (HEK293) from α- and β-Zearalenol-induced ER stress and apoptosis. | LitMetric

Crocin protects human embryonic kidney cells (HEK293) from α- and β-Zearalenol-induced ER stress and apoptosis.

Environ Sci Pollut Res Int

Laboratory for Research on Biologically Compatible Compounds (LRSBC), Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia.

Published: August 2016

AI Article Synopsis

  • * This ER stress leads to apoptosis through mitochondrial pathways, marked by increased ROS generation, lipid peroxidation, and activation of cellular caspases.
  • * Crocin (CRO), a compound found in saffron, exhibits antioxidant properties that may protect against ER stress and reduce apoptosis caused by α- and β-ZOL in kidney cells.

Article Abstract

α-zearalenol (α-ZOL) and β-zearalenol (β-ZOL) are the major metabolites of Zearalenone (ZEN) and are known to induce many toxic effects. In the present study, we investigated the involvement of endoplasmic reticulum (ER) stress in α- and β-ZOL-mediated toxicity in human kidney cells (HEK293) and evaluated the effect of a common dietary compound Crocin (CRO), from saffron. We show that α- and β-ZOL treatment induces ER stress as evidenced by the upregulation of the 78 kDa glucose-regulated protein (GRP78) and the Growth arrest and DNA damage-inducible protein (GADD34). Activation of the ER stress response is associated with activation of the mitochondrial pathway of apoptosis. This apoptotic process is characterized by an increase in ROS generation and lipid peroxidation, a loss of mitochondrial transmembrane potential (ΔΨm) and activation of caspases. We also demonstrate that the antioxidant properties of CRO help to prevent ER stress and reduce α- and β-ZOL-induced apoptosis in HEK293 cells. Our results suggest that saffron consumption might be helpful to prevent α- and β-ZOL-induced ER stress and toxicity.

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Source
http://dx.doi.org/10.1007/s11356-016-6741-yDOI Listing

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