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Employing the Oncolytic Vesicular Stomatitis Virus in Cancer Virotherapy: Resistance and Clinical Considerations.
Viruses
December 2024
Thomas H. Gosnell School for Life Sciences, Rochester Institute of Technology, Rochester, NY 14623, USA.
Vesicular Stomatitis Virus (VSV) has emerged as a promising candidate for various clinical applications, including vaccine development, virus pseudotyping, and gene delivery. Its broad host range, ease of propagation, and lack of pre-existing immunity in humans make it ideal for therapeutic use. VSV's potential as an oncolytic virus has garnered attention; however, resistance to VSV-mediated oncolysis has been observed in some cell lines and tumor types, limiting its effectiveness.
View Article and Find Full Text PDFBioactive Sesquiterpenoids from L. Flowers: Chemical Profiling and Antifungal Activity Against Species.
Plants (Basel)
January 2025
Department of Agricultural and Forestry Engineering, ETSIIAA, Universidad de Valladolid, Avenida de Madrid 44, 34004 Palencia, Spain.
L. (cotton-lavender) is receiving increasing attention due to its potential for modern medicine and is considered both a functional food and nutraceutical. In this work, the phytochemical profile of its flower hydromethanolic extract was investigated by gas chromatography-mass spectrometry, and its applications as a biorational for crop protection were explored against spp.
View Article and Find Full Text PDFComplete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China.
Pathogens
January 2025
Jiaxing Key Laboratory of Pathogenic Microbiology, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, China.
Mpox, a zoonotic disease caused by the mpox virus (MPXV), has seen a significant shift in its epidemiological status since 2022, evolving from an initial local outbreak to a global epidemic. This recent outbreak of MPXV mainly emerged in several European and American countries and subsequently spread to over 100 countries and regions worldwide. The rapid evolution of MPXV, coupled with increased international interactions, has led to a gradual rise in mpox cases in certain regions of Asia, mostly involving MPXV clade II and its branch strains.
View Article and Find Full Text PDFSeed Protein Content Estimation with Bench-Top Hyperspectral Imaging and Attentive Convolutional Neural Network Models.
Sensors (Basel)
January 2025
Department of Earth, Environment and Geospatial Sciences, Saint Louis University, Saint Louis, MO 63108, USA.
Wheat is a globally cultivated cereal crop with substantial protein content present in its seeds. This research aimed to develop robust methods for predicting seed protein concentration in wheat seeds using bench-top hyperspectral imaging in the visible, near-infrared (VNIR), and shortwave infrared (SWIR) regions. To fully utilize the spectral and texture features of the full VNIR and SWIR spectral domains, a computer-vision-aided image co-registration methodology was implemented to seamlessly align the VNIR and SWIR bands.
View Article and Find Full Text PDFA Systematic Review of Micropulse Laser Trabeculoplasty (MLT) in Primary Open-Angle Glaucoma (POAG) Management: Efficacy, Safety, and Future Perspectives.
Biomedicines
January 2025
Institute of Ophthalmology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, 41122 Modena, Italy.
Background/objectives: Micropulse laser trabeculoplasty (MLT) is gaining attention as a non-invasive treatment option for primary open-angle glaucoma (POAG), offering an alternative to traditional surgeries and medications. This systematic review evaluates the effectiveness, safety, and potential of MLT in glaucoma management.
Methods: This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
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