Comminuted radial head fractures are usually associated with destabilizing lesions of the elbow. The radial head prosthesis (RHP) is a therapeutic alternative when fracture fixation is impossible, as it restores one of the elbow's secondary stabilizers. The aim of this study was to assess healing of the medial collateral ligament (MCL) after implantation of a RHP. All patients implanted with a RHP during the 2003-2012 period were eligible for follow-up ultrasound evaluation of MCL healing. A clinical evaluation with standardized tests (DASH and MEPS) was performed and the patients asked to evaluate their elbow's stability during the same follow-up visit. Out of the 33 eligible patients, 20 were included with a mean follow-up of 73 months. The MCL had been torn in 15 of these 20 patients; the MCL appeared healed on the ultrasound images in 13 patients. The elbow was considered subjectively stable in 19 patients. The mean DASH score was 21.4 (±16.67) and the mean MEPS was 84.7 (±13.9); these scores were 17.19 (±14.0) and 88.3 (±10.9) for patients with a healed MCL, versus 32.5 (±10.6) and 70 (±0.0) for patients with a non-healed MCL. Our findings suggest that a torn MCL can heal after RHP implantation, even without surgical ligament repair or reattachment.
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http://dx.doi.org/10.1016/j.hansur.2015.12.005 | DOI Listing |
Case: We present a 79-year-old woman with a complex elbow fracture including a comminuted proximal ulna fracture, coronoid process fracture, and comminuted radial head fracture treated with primary total elbow arthroplasty (TEA). The patient completed an early therapy protocol and had complete healing. At 15 months postoperatively, she had full pronosupination and elbow arc of motion from 10 to 135° with no reported pain.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
Background: In the context of pathological aging and Alzheimer's disease (AD), the overexpression of calcineurin has been identified as a factor linked to astrocyte reactivity, neuronal death, and inflammation. This suggests that inhibiting calcineurin or downstream nuclear factor of activated T cells (NFAT) signaling could be a promising strategy for preventing or slowing down AD pathophysiology.
Method: Baseline and annual MRI sessions including higher-order diffusion-weighted imaging was performed over four years on 43 dogs ranging from 5 to 8.
Background: Repetitive mild traumatic brain injury (rmTBI) represents a substantial health challenge, urging a more thorough investigation into its early effects and possible interventions. The collective consequences of rmTBI encompass various neurobiological and neuropsychological impairments, increasing susceptibility to diseases like Alzheimer's and related dementias. Employing the Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) approach for TBI induction, our prior study revealed connectivity alterations within 53% of regions in young and aged wild-type mice five days post-injury.
View Article and Find Full Text PDFJ Pediatr Orthop B
January 2025
Trauma Research Center, Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Hereditary multiple exostoses is an autosomal dominant genetic condition primarily affecting long bones. Forearm deformities, including wrist ulnar deviation, ulnar shortening, radial or ulnar bowing, and radial head dislocation, are common manifestations. Gradual ulnar lengthening is suggested as a viable treatment option for managing these deformities.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Florida, Gainesville, FL, USA.
Background: Repetitive mild traumatic brain injury (rmTBI) represents a substantial health challenge, urging a more thorough investigation into its early effects and possible interventions. The collective consequences of rmTBI encompass various neurobiological and neuropsychological impairments, increasing susceptibility to diseases like Alzheimer's and related dementias. Employing the Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) approach for TBI induction, our prior study revealed connectivity alterations within 53% of regions in young and aged wild-type mice five days post-injury.
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