[Disorders of hypothalamico-pituitary regulation of adrenal and ovarian function in women suffering from Itsenko-Cushing disease].

Data are reported of the functional state of the hypothalamoadrenal system in 119 women with Itsenko-Cushing disease in the active stage, stage of stable clinical remission and after total adrenalectomy. It was established that the most pronounced changes of the relationship of pituitary, adrenal, uterine hormones were found in the active stage of the disease. This leads to disorders of the menstrual cycle according to the type of hypomenstrual syndrome, polycystic degeneration of the ovaries and infertility. In the state of stable remission after treatment and after adrenalectomy, hypothalamo-pituitary-adrenal relationships were found to be within normal limits; this resulted in restoration of the menstrual cycle and fertility.