RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allowing detection of DNA damage hidden in chromatin structure.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984681 | PMC |
| http://dx.doi.org/10.1080/21541264.2016.1182240 | DOI Listing |
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