AI Article Synopsis
- Transgenic mice have been created to express active Fyn tyrosine kinase, which is controlled by a specific promoter that activates during the early stages of myelination in the peripheral nervous system (PNS).
- The phosphorylation of cytohesin-1 by Fyn is crucial for starting and regulating myelination during development, as indicated by research from Yamauchi et al. (2015).
- The study presents data on myelination-related protein markers and the ultrastructure of myelin in these transgenic mice.
Article Abstract
Transgenic mice, which express active Fyn tyrosine kinase under the control of a glial fibrillary acidic protein promoter, have been produced. This promoter induces protein expression in the initiation stage of myelination in the peripheral nervous system (PNS) "Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development (Yamauchi et al., 2015 [1])". Herein we provide the data regarding myelination-related protein markers and myelin ultrastructure in transgenic mice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833127 | PMC |
| http://dx.doi.org/10.1016/j.dib.2016.03.096 | DOI Listing |
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