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Experimental study on hydrophysical properties and slope planting of ecological composite material solidified loess.
J Environ Manage
January 2025
School of Geological Engineering and Geomatics, Chang'an University, Xi'an, 710054, China. Electronic address:
The construction of engineering projects in the Chinese Loess Plateau has resulted in large areas of exposed slopes, increasing the risk of soil erosion. Restoring the slope ecosystem is an effective means to reduce soil erosion, prevent soil and water loss, and maintain slope stability. Ecological slope protection using bio-gum solidified fiber-reinforced loess (GFSL) has been proven to achieve good vegetation restoration effects, but there remains a problem of low vegetation coverage in the early stage of protection.
View Article and Find Full Text PDFStructure-based design of new anticancer N3-Substituted quinazolin-4-ones as type I ATP-competitive inhibitors targeting the deep hydrophobic pocket of EGFR.
Comput Biol Med
January 2025
Drug Design and Discovery Lab, Helmy Institute of Medical Sciences, Zewail City of Science, Technology and Innovation, Giza, 12578, Egypt; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science, Technology and Innovation, Giza, 12578, Egypt. Electronic address:
Epidermal growth factor receptor (EGFR) is amongst the earliest targeted kinases by small-molecule inhibitors for the management of EGFR-positive cancer types. While a few inhibitors are granted FDA approval for clinical use, discovery of new inhibitors is still of merit to enhance ligand-binding stability and subsequent enzyme inhibition. Thus, a structure-based design approach was adopted to devise a new series of twenty-nine N3-substituted quinazolin-4-ones as type I ATP-competitive inhibitors targeting the deep hydrophobic pocket of EGFR.
View Article and Find Full Text PDFThe role of taxation in environmental sustainability in G-20 economies: A double dividend theoretical assessment.
J Environ Manage
January 2025
School of Economics, Beijing Institute of Technology, Beijing, China; GUST Center for Sustainable Development (CSD), Gulf University for Science and Technology, Hawally, Kuwait; University of Economics and Human Science in Warsaw, Warsaw, Poland. Electronic address:
This study analyses the influence of environmental taxes, renewable energy, economic growth, green innovation and financial development on environmental sustainability in G-20 countries from 1990 to 2022. To this end, the Method of Moments Quantile Regression (MMQR) was applied to obtain the reference results, complemented with Fully Modified Ordinary Least Square (FMOLS) and Driscoll-Kraay techniques to perform a comparative analysis. Our results confirm a negative relationship between environmental taxes and sustainability in all quantiles, although this relationship is only significant in the middle and upper quantiles.
View Article and Find Full Text PDFPhylogenetic characterization of Bifidobacterium kimbladii sp. nov., a novel species from the honey stomach of the honeybee Apis mellifera.
Syst Appl Microbiol
January 2025
Department of Laboratory Medicine, Medical Microbiology, Lund University, Medicon Village, SE-223 81 Lund, Sweden.; ConCellae AB, Bårslövsvägen 3, 25373 Helsingborg, Sweden.
Six novel Bifidobacterium strains H1HS16N, Bin2N, Hma3N, H6bp22N, H1HS10N, and H6bp9N, were isolated from the honey stomach of Apis mellifera. Cells are Gram-positive, non-motile, non-sporulating, facultatively anaerobic, and fructose 6-phosphate phosphoketolase-positive. Optimal growth conditions occur at 37 °C in anaerobiosis in MRS medium added with 2 % fructose and 0.
View Article and Find Full Text PDFNGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate enhances the antitumor effect of quercetin liposomes in triple-negative breast cancer.
Pharm Dev Technol
January 2025
Department of Pharmacy, School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
In this paper, the pH-sensitive targeting functional material NGR-poly(2-ethyl-2-oxazoline)-cholesteryl methyl carbonate (NGR-PEtOz-CHMC, NPC) modified quercetin (QUE) liposomes (NPC-QUE-L) was constructed. The structure of NPC was confirmed by infrared spectroscopy (IR) and nuclear magnetic resonance hydrogen spectrum (H-NMR). Pharmacokinetic results showed that the accumulation of QUE in plasma of the NPC-QUE-L group was 1.
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