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Background: Accumulating evidence highlights impairment of autophagy as a key pathological feature of neurodegenerative diseases including Alzheimer's disease (AD). Autophagy is a highly dynamic, lysosome-based degradation process that promotes the clearance of degenerative factors to maintain cellular functions, preserve metabolic integrity, and ensure survival. Impaired autophagic function leads to the abnormal accumulation of autophagic vesicles (i.
View Article and Find Full Text PDFBackground: Alzheimer's disease is the most dreaded multifactorial neurological illness for which there is currently no known treatment. Although the exact cause of AD is still unknown, several factors related to lifestyle, genetics, and environment are known to have a significant role in the disease's development. Alzheimer's disease is characterized by neuronal loss, neurofibrillary tangles, and senile plaques.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of California San Francisco, San Francisco, CA, USA.
Background: Family caregivers of persons living with dementia (PLWD) in rural areas of the United States (U.S.) are isolated, under-served, and experience poor health outcomes.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
University of Pittsburgh Alzheimer's Disease Research Center (ADRC), Pittsburgh, PA, USA.
Background: Increasing calls for diversity in Alzheimer's disease and related dementias (ADRDesearch have fueled significant investments in recruitment personnel and activities. However, the essential work of identifying and authentically engaging communities of color in relationship-building begins well before, and continues long after, study recruitment activities take place. The purpose of this presentation is twofold: 1) to differentiate the work of trust-building and relationship cultivation from that of research study recruitment, and 2) to describe the necessary steps to ensure that relationship cultivation is ongoing and supported beyond the timeline of a singular research study.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Background: Understanding social, behavioral, and environmental determinants of health (SBEDOH) are key in identifying modifiable risk factors for Alzheimer's Disease and related Dementias (ADRD), particularly the disproportionate burden seen in minorities. However, a lack of standardized SBEDOH methods exists with current methods limited in scope and cultural sensitivity (i.e.
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