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CXCL9/CXCL10 as biomarkers the monitoring of treatment responses in Pulmonary TB patients: a systematic review and meta-analysis.
BMC Infect Dis
September 2024
State Key Laboratory of Respiratory Disease, Guangzhou Key Laboratory of Tuberculosis Research, Institute of Pulmonary Diseases, Guangzhou Chest Hospital, Institute of Tuberculosis, Guangzhou Medical University, 62 Hengzhigang Rd, Yuexiu District, Guangzhou, 510095, People's Republic of China.
Background: Tuberculosis (TB) remains a persistent threat to global public health and traditional treatment monitoring approaches are limited by their potential for contamination and need for timely evaluation. Therefore, new biomarkers are urgently required for monitoring the treatment efficacy of TB.
Methods: This study aimed to elucidate the levels of CXCL10 and CXCL9 in pulmonary TB patients who underwent anti-TB treatment.
Comparison of serum cytokines and chemokines levels and clinical significance in patients with pemphigus vulgaris-A retrospective study.
Exp Dermatol
September 2024
Department of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Article Synopsis
- This study investigated the connection between cytokine levels, disease severity (measured by PDAI), and specific antibodies in patients with pemphigus vulgaris (PV) compared to healthy individuals.
- It involved 62 PV patients and examined various cytokines and chemokines, which revealed increased levels of certain Th1, Th2, and Th17/Th22 cytokines in the PV group, but lower levels of specific chemokines.
- The research also found significant correlations between certain cytokines and disease severity, as well as associations between specific cytokines and antibody levels, suggesting a complex immune response in PV patients.
The mediating effect of maternal gut microbiota between prenatal psychological distress and neurodevelopment of infants.
J Affect Disord
October 2024
Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China; Wuhan University School of Nursing, Wuhan University, 169 Donghu Road, Wuhan 430071, Hubei, China. Electronic address:
Background: Prenatal psychological distress and maternal inflammation can increase the risk of neurodevelopmental delay in offspring; recently, the gut microbiota has been shown to may be a potential mechanism behind this association and not fully elucidated in population study.
Methods: Seventy-two maternal-infant pairs who completed the assessments of prenatal psychological distress during the third trimester and neurodevelopment of infants at age 6-8 months of age were included in this study. The gut microbiota and its short-chain fatty acids (SCFAs) of maternal-infant were determined by 16S rRNA sequencing and liquid chromatography-mass spectrometry analysis.
Crosstalk between vault RNAs and innate immunity.
Mol Biol Rep
March 2024
Universidad Autónoma del Estado de México (UAEMex), Toluca, Estado de México, Mexico.
Purpose: Vault (vt) RNAs are noncoding (nc) RNAs transcribed by RNA polymerase III (RNA Pol III) with 5'-triphosphate (5'-PPP) termini that play significant roles and are recognized by innate immune sensors, including retinoic acid-inducible protein 1 (RIG-I). In addition, vtRNAs adopt secondary structures that can be targets of interferon-inducible protein kinase R (PKR) and the oligoadenylate synthetase (OAS)/RNase L system, both of which are important for activating antiviral defenses. However, changes in the expression of vtRNAs have been associated with pathological processes that activate proinflammatory pathways, which influence cellular events such as differentiation, aging, autophagy, apoptosis, and drug resistance in cancer cells.
View Article and Find Full Text PDFAnalysis of Cytokine Levels Based on Optical Coherence Tomography Findings in Acute and Chronic Central Serous Chorioretinopathy.
Curr Eye Res
December 2023
Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P.R. China.
To investigate the characteristics of optical coherence tomography (OCT) and aqueous humor cytokine differences between acute and chronic central serous chorioretinopathy (CSC) and to evaluate the relevance of these findings. This was a cross-sectional, observational study. Patients with CSC were divided into acute and chronic groups based on the symptom duration and were compared with normal controls.
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