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http://dx.doi.org/10.1002/1873-3468.12164 | DOI Listing |
FEBS Lett
August 2002
Swiss Science and Technology Council, Bern, Switzerland.
FEBS Lett
February 2002
Swiss Science and Technology Council, Bern, Switzerland.
Mol Endocrinol
May 2000
Affymax Research Institute, Santa Clara, California 95051, USA.
Steroid and thyroid hormone receptors are members of the superfamily of nuclear receptors (NR) that participate in developmental and homeostatic mechanisms by changes in the transcription of specific genes. These activities are governed by the receptors' cognate ligands and through interaction with the components of the transcriptional machinery. A number of coactivator molecules of the steroid receptor coactivator (SRC)/nuclear receptor coactivator (NCoA) family interact with activation functions within NRs through a conserved region containing helical domains of a core LXXLL sequence and, thereby, participate in transcriptional regulation.
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