Nitroxyl or azanone (HNO) represents the redox-related (one electron reduced and protonated) relative of the well-known biological signaling molecule nitric oxide (NO). Despite the close structural similarity to NO, defined biological roles and endogenous formation of HNO remain unclear due to the high reactivity of HNO with itself, soft nucleophiles and transition metals. While significant work has been accomplished in terms of the physiology, biology and chemistry of HNO, important and clarifying work regarding HNO detection and formation has occurred within the last 10 years. This review summarizes advances in the areas of HNO detection and donation and their application to normal and pathological biology. Such chemical biological tools allow a deeper understanding of biological HNO formation and the role that HNO plays in a variety of physiological systems.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910183 | PMC |
| http://dx.doi.org/10.1016/j.niox.2016.04.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Vacuum Ultraviolet (UV) Photoreactor-Based Flow Droplet Digestion for Determination of Arsenic and Mercury in Blood by Atomic Fluorescence Spectrometry.
Anal Chem
January 2025
Key Laboratory of Green Chemistry & Technology of MOE, College of Chemistry, Sichuan University, Chengdu, Sichuan610064, China.
It is still challenging to perform a high-throughput digestion on limited amounts of sample prior to elemental analysis by atomic spectrometry. Herein, a photochemical reactor consisting of a quartz tube inserted into a low-pressure mercury lamp was used to fabricate a flow droplet photodigestion (FD-PD) device for the high-throughput digestion of small amounts of samples. A mixture containing 20 μL of blood sample, 20 μL of HO, and 10 μL of HNO was pumped and passed through the reactor before its online analysis by hydride generation atomic fluorescence spectrometry (HG-AFS).
View Article and Find Full Text PDFSimultaneous quantification of Hg(II) and Pb(II) by square wave anodic stripping voltammetry using Bi/graphite electrode.
Heliyon
July 2024
Engineering Faculty, Department of Environmental and Chemical Engineering, Universidad Nacional de Colombia, Colombia.
In the present work, we report the synthesis and evaluation of a graphite-supported bismuth film working electrode (BiFE) in the simultaneous quantification of Hg(II) and Pb(II) at ppb levels. The BiFE was synthesized in-situ by electrodeposition in 1 M HNO as the supporting electrolyte at -0.5 V potential.
View Article and Find Full Text PDFSearching for nitroxyl modulators in Arabidopsis thaliana - a new paradigm of redox signaling in plant.
J Exp Bot
January 2025
Department of Plant Ecophysiology, Faculty of Biology, Adam Mickiewicz University; Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.
Through extensive research, nitroxyl (HNO) has emerged as a newly recognized redox signal in plant developmental and stress responses. The interplay between nitric oxide (●NO) and HNO entails a complex network of signaling molecules and regulatory elements sensitive to the environment's specific redox conditions. However, functional implications for HNO in cell signaling require more detailed studies, starting with identifying HNO-level switches.
View Article and Find Full Text PDFNear-infrared fluorescent probe for visualization of nitroxyl in the plant response to stress.
Anal Chim Acta
January 2025
College of Tobacco Science, Henan Agricultural University, Zhengzhou, 450046, China. Electronic address:
Background: Nitroxyl (HNO) is an emerging signaling molecule that plays a significant regulatory role in various aspects of plant biology, including stress responses and developmental processes. However, understanding the precise actions of HNO in plants has been challenging due to the absence of highly sensitive and real-time in situ monitoring tools. Consequently, it is crucial to develop effective and accurate detection methods for HNO.
View Article and Find Full Text PDFAn Innovative Food Processing Technology: Microwave Electrodeless Ultraviolet, Luminescence Mechanism, Microbial Inactivation, and Food Application.
Foods
December 2024
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.
Microwave electrodeless ultraviolet (MWUV) technology, as an emerging food processing technique, has garnered growing attention in the realm of food science in recent years. Based on different application requirements, MWUV equipment types are categorized as microwave oven reactor, continuous-flow UV-microwave reactor, coaxially driven MWUV reactor, and complete ultraviolet reactor. The luminescence properties of MWUV equipment depend on their filler gas; mercury is commonly used as a filler gas to produce a wavelength at 253.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!