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Acquired cystic kidney disease in children with kidney failure.
Pediatr Nephrol
January 2025
Paediatric Nephrology Centre, Hong Kong Children's Hospital, Hong Kong, Hong Kong SAR.
Background: This study aimed to evaluate the incidence, contributing factors, and clinical outcomes of acquired cystic kidney disease (ACKD) in children undergoing kidney replacement therapy (KRT).
Methods: We conducted a cross-sectional, territory-wide study at the designated pediatric nephrology center in Hong Kong. ACKD was defined as the presence of ≥ 3 cysts in the native kidneys, excluding congenital or hereditary cystic diseases.
A good response to furmonertinib fourth-line treatment of an advanced lung adenocarcinoma patient with EGFR exon20in and PIK3CA mutation: a case report and literature review.
Front Oncol
December 2024
Department Oncology, Yidu Central Hospital of Weifang, Weifang, China.
Article Synopsis
- Lung cancer is the leading cancer globally, with EGFR mutations common in female NSCLC patients, necessitating targeted therapies like TKIs, though resistance often develops.
- A case study details a 63-year-old woman with both lung adenocarcinoma and renal cancer; she initially responded well to standard treatments but faced resistance.
- The use of furmonertinib, a third-generation EGFR-TKI, resulted in a remarkable 27 months of progression-free survival, showcasing its effectiveness against complex resistance pathways.
Mechanism of Fangji Huangqi decoction against acute kidney injury based on network pharmacology and experimental validation.
Phytomedicine
December 2024
Department of Traditional Chinese Medicine, Qingdao Municipal Hospital, Qingdao, PR China. Electronic address:
Background: Fangji Huangqi Decoction (FJHQD), a famous Traditional Chinese Medicine (TCM) formula, has been widely applied in improving renal function. However, the interaction of bioactives from FJHQD with the targets involved in acute renal injury (AKI) has not been elucidated yet.
Purpose: A network pharmacology-based approach combined with molecular docking and in vitro and in vivo validation was performed to determine the bioactives, key targets, and potential pharmacological mechanism of FJHQD against AKI.
The clinical indexes and immunological status of HIV/AIDS patients undergoing different highly active antiretroviral treatments.
Front Cell Infect Microbiol
January 2025
Yunnan Key Laboratory of Laboratory Medicine, Kunming, China.
Objective: This study aims to investigate the differences of clinical indices in HIV patients between three different first-line antiretroviral treatment strategies in Yunnan Province, China. Furthermore, the hematologic system, liver function, kidney function, blood lipid levels of HIV patients and its association with CD4+ count, CD8+ count, CD4/CD8 ratio and antiretroviral treatment were also assessed.
Methods: This retrospective cohort study included 81 participants who underwent highly active antiretroviral treatment from September 2009 to September 2019.
Calciphylaxis: A Case Report and Review of the Role of Sodium Thiosulphate and Other Treatment Modalities.
Cureus
November 2024
Nephrology, Colchester Hospital, Colchester, GBR.
Calciphylaxis is a rare and serious disorder almost exclusively seen in patients on dialysis or those with advanced chronic kidney disease (CKD) not on dialysis and is associated with very high mortality. We present the case of a 50-year-old male with a background of end-stage renal disease (ESRD) compliant with dialysis, parathyroid adenoma, secondary hyperparathyroidism, and high body mass index (BMI). Whilst receiving 31 doses of intravenous sodium thiosulphate (STS) over an 11-week period, the patient underwent surgical debridement of multiple painful ulcerative lesions in his lower abdomen and left thigh and then subsequently a subtotal parathyroidectomy at 70 days from admission.
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