Toxicodynetics: A new discipline in clinical toxicology.

Ann Pharm Fr

Département d'anesthésie-réanimation, SAMU 75, réanimation adulte polyvalente, groupe hospitalier Necker, Assistance publique-Hôpitaux de Paris, 75015 Paris, France.

Published: May 2016

Objectives: Regarding the different disciplines that encompass the pharmacology and the toxicology, none is specifically dedicated to the description and analysis of the time-course of relevant toxic effects both in experimental and clinical studies. The lack of a discipline devoted to this major field in toxicology results in misconception and even in errors by clinicians.

Material And Methods: Review of the basic different disciplines that encompass pharmacology toxicology and comparing with the description of the time-course of effects in conditions in which toxicological analysis was not performed or with limited analytical evidence.

Results: Review of the literature clearly shows how misleading is the current extrapolation of toxicokinetic data to the description of the time-course of toxic effects.

Conclusion: A new discipline entitled toxicodynetics should be developed aiming at a more systematic description of the time-course of effects in acute human and experimental poisonings. Toxicodynetics might help emergency physicians in risk assessment when facing a poisoning and contribute to a better assessment of quality control of data collected by poison control centres. Toxicodynetics would also allow a quantitative approach to the clinical effects resulting from drug-drug interaction.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharma.2016.02.003DOI Listing

Publication Analysis

Top Keywords

description time-course
12
disciplines encompass
8
encompass pharmacology
8
pharmacology toxicology
8
time-course effects
8
toxicodynetics
4
toxicodynetics discipline
4
discipline clinical
4
toxicology
4
clinical toxicology
4

Similar Publications

Introduction: While considerable research in language production has focused on incremental processing during conceptual and grammatical encoding, prosodic encoding remains less investigated. This study examines whether focus and accentuation processing in speech production follows linear or hierarchical incrementality.

Methods: We employed visual world eye-tracking to investigate how focus and accentuation are processed during sentence production.

View Article and Find Full Text PDF

Importance: Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening complication of COVID-19 infection. Data on midterm outcomes are limited.

Objective: To characterize the frequency and time course of cardiac dysfunction (left ventricular ejection fraction [LVEF] <55%), coronary artery aneurysms (z score ≥2.

View Article and Find Full Text PDF

There is an increasing understanding that some mitral valve pathologies have developmental origins. The time course of valvulogenesis varies by animal model; in cattle, the branched chordae tendineae architecture becomes fully developed at full term. The mechanism by which chordae tendineae bifurcate during fetal development remains unknown.

View Article and Find Full Text PDF

Description: Nonampullary duodenal polyps are found in up to 5% of all upper endoscopies; the vast majority are identified incidentally in asymptomatic patients. Although most are benign, adenomas are estimated to account for 10%-20% of these lesions. Most international guidelines recommend that all duodenal adenomas should be considered for endoscopic resection; this may be associated with a near 15% adverse event rate (predominantly bleeding and perforation) in prospective studies, with substantial local recurrence on surveillance.

View Article and Find Full Text PDF

Introduction: The aim of the article is to determine the appropriate concentration of desflurane to effectively counteract the increase in blood pressure resulting from surgical stress. In medical practice, this increase is often limited by using additional doses of opioid drugs. Additional medications or higher doses of those already used may adversely affect your health.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!