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The Role of Lymphstasis in Atherogenesis Revisited.
Ann Thorac Surg
May 2016
Temple University School of Medicine, 3500 N Broad St, Philadelphia, PA19140. Electronic address:
“The Role of Lymphstasis in Atherogenesis” appeared in the Annals of Thoracic Surgery in the March 1981 issue which examined the significance of lymphatic involvement in arteriosclerosis. Presently, the underlying premise of the original paper is reviewed with its relationship to recent information regarding reverse cholesterol transport.Since then, an ncreasing number of articles have been published identifying the proteins and peptides that play a critical role in lymphatic clearance of arterial wall cholesterol.
View Article and Find Full Text PDFThe cardiac lymphatics are responsible for the transport of all the lipoproteins and cholesterol from the extravascular myocardial tissue, although little is known about the filtration and lymphatic clearance of the coronary artery wall. It is postulated that a critical factor in the genesis of arteriosclerosis is lymphstasis, which adequately explains the positive correlation with the known risk factors for coronary artery disease and the negative correlation with high-density lipoproteins. Further research is necessary in this little-known area to better understand the etiology of atherosclerosis.
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