From a systems biology perspective, the brain and spinal cord are interwoven with the body: they are ‘embodied’. Freund . propose an integrative framework based on biophysical models that aims to characterize neurological disorders and minimize their impact on patients by considering functional interactions between supra-spinal, spinal and peripheral regions simultaneously.
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http://dx.doi.org/10.1093/brain/aww076 | DOI Listing |
Chem Asian J
January 2025
Kyoto University, Institute for Integrated Cell-Material Sciences, Yoshida, Sakyo-ku, 606-8501, Kyoto, JAPAN.
The architectural characteristics of metal-organic frameworks (MOFs) can be examined through their net topology, which consists of nodes and linkers. A node's connectivity and site symmetry are likely the key elements influencing the net topology of MOFs. Metal-organic polyhedra (MOPs) function effectively as nodes when used as supermolecular building blocks (SBBs).
View Article and Find Full Text PDFAust J Rural Health
February 2025
Murtupuni Centre for Rural and Remote Health, James Cook University, Townsville, Queensland, Australia.
Objective: This study aimed to explore the perspectives of healthcare professionals on the utility of sick day management plans for people with chronic kidney disease (CKD) in remote communities and collaboratively design a sick day management plan resource.
Design: This qualitative study utilised two phases of data collection: preliminary observational data and semi-structured interviews. The research design and analysis were guided by the normalisation process theory (NPT) framework, tailored for complex interventions in healthcare.
Immunol Cell Biol
January 2025
Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Natural killer (NK) cells are emerging agents for cancer therapy. Several different cytokines are used to generate NK cells for adoptive immunotherapy including interleukin (IL)-2, IL-12, IL-15 and IL-18 in solution, and membrane-bound IL-21. These cytokines drive NK cell activation through the integration of signal transducers and activators of transcription (STAT) and nuclear factor-kappa B (NF-κB) pathways, which overlap and synergize, making it challenging to predict optimal cytokine combinations for both proliferation and cytotoxicity.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Computer Science and Engineering, Engineering College Ajmer, Ajmer, Rajasthan, India.
To combat dynamically loaded code in anti-emulated environments, DLCDroid is an Android app analysis framework. DL-CDroid uses the reflection API to effectively identify information leaks due to dynamically loaded code within malicious apps, incorporating static and dynamic analysis techniques. The Dynamically Loaded Code (DLC) technique employs Java features to allow Android apps to dynamically expand their functionality at runtime.
View Article and Find Full Text PDFSci Rep
January 2025
Institute of Mechanical Science, Vilnius Gediminas Technical University, Vilnius, 10105, Lithuania.
Digital transformation (DT) has become vital for companies trying to remain competitive in the recent ever-changing technological environment. DT is the integration of digital technologies into all disciplines of business from regular activities to strategic decision making. Risk management planning requires projects to assess possible risks that may negatively or positively affect a DT project.
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