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Diagnostic value of urinary and serum IgG antibodies in evaluating drug treatment response in strongyloidiasis assessed by fecal examination and digital droplet PCR.
PLoS One
December 2024
Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Detection of Strogyloides-specific IgG antibodies in urine and serum has been used in diagnostic and epidemiological studies on strongyloidiasis. However, the usefulness of these assays in assessing responses to anthelmintic treatment is unclear. Thus, we evaluated the diagnostic performance and temporal profiles of Strongyloides-specific IgG antibodies in a cohort of participants at baseline and post-treatment.
View Article and Find Full Text PDFPathogenic mitochondrial DNA mutations inhibit melanoma metastasis.
Sci Adv
November 2024
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Mitochondrial DNA (mtDNA) mutations are frequent in cancer, yet their precise role in cancer progression remains debated. To functionally evaluate the impact of mtDNA variants on tumor growth and metastasis, we developed an enhanced cytoplasmic hybrid (cybrid) generation protocol and established isogenic human melanoma cybrid lines with wild-type mtDNA or pathogenic mtDNA mutations with partial or complete loss of mitochondrial oxidative function. Cybrids with homoplasmic levels of pathogenic mtDNA reliably established tumors despite dysfunctional oxidative phosphorylation.
View Article and Find Full Text PDFReward Neurocircuitry Predicts Longitudinal Changes in Alcohol Use Following Trauma Exposure.
Biol Psychiatry Cogn Neurosci Neuroimaging
March 2025
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
Article Synopsis
- Trauma can increase the risk of unhealthy alcohol use, and this study investigates how brain reward systems change after trauma exposure in humans.
- The research involved 286 participants who were assessed for changes in alcohol use and brain activity through fMRI shortly after experiencing trauma.
- Findings suggest that heightened brain activity in specific regions (like the VTA) and altered connections between brain areas may lead to increased alcohol consumption following traumatic events, indicating potential targets for early intervention.
Mitochondrial complex I promotes kidney cancer metastasis.
Nature
September 2024
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Most kidney cancers are metabolically dysfunctional, but how this dysfunction affects cancer progression in humans is unknown. We infused C-labelled nutrients in over 80 patients with kidney cancer during surgical tumour resection. Labelling from [U-C]glucose varies across subtypes, indicating that the kidney environment alone cannot account for all tumour metabolic reprogramming.
View Article and Find Full Text PDFMaternal posture-physiology interactions in human pregnancy: a narrative review.
Front Physiol
July 2024
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States.
Article Synopsis
- The review examines the relationships between maternal posture and health dynamics during pregnancy, emphasizing how gravity and body position impact physiological and pathophysiological processes.
- A systematic literature search identified 644 relevant studies published between 1991 and 2021, revealing discrepancies and research gaps in understanding these interactions across multiple organ systems, particularly in the circulatory system.
- The authors highlight the need for further research and clinical developments to better understand maternal posture's effects on health, which is essential for improving care during pregnancy and postpartum.
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