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Methotrexate toxicity-response.
Autoimmun Rev
December 2016
Department of Medicine E, The Chaim Sheba Medical Center, Ramat-Gan, Israel; Sackler School of Medicine, Ramat-Aviv, Israel.
Association of SLCO1B1 gene polymorphisms with toxicity response of high dose methotrexate chemotherapy in childhood acute lymphoblastic leukemia.
Int J Clin Exp Med
July 2015
Department of Hematology and Oncology, Children's Hospital of Fudan University No. 399 Wanyuan Road, Shanghai, 201102, P.R. China.
Objective: The present study aims to investigate the correlation of polymorphisms of SLCO1B1 gene with the toxicity during therapy with the high-dose methotrexate (MTX) chemotherapy in childhood acute lymphoblastic leukemia.
Methods: We analyzed 2 polymorphisms (rs4149081 and rs11045897) in SLCO1B1 gene in 280 Chinese pediatric B-ALL patients, using MTX plasma concentration as an objective and quantifiable marker of toxicity. We utilized Enzyme-multiplied immunoassay technique (EMIT) to measure the plasma concentration of MTX.
[Influence of thymidylate synthase gene polymorphisms on high-dose methotrexate-related toxicities in childhood acute lymphoblastic leukemia].
Zhongguo Dang Dai Er Ke Za Zhi
January 2015
Department of Pediatrics, First Affiliated Hospital of Hunan Normal University/Hunan Province People's Hospital, Changsha 410005, China.
Objective: To investigate the influence of thymidylate synthase (TS) gene polymorphisms on high-dose methotrexate (HD-MTX)-related toxicities in childhood acute lymphoblastic leukemia (ALL).
Methods: A total of 73 children who were diagnosed with ALL between March 2011 and March 2013 were included into this study. Genomic DNAs were extracted from their peripheral blood.
[Association between the methylenetetrahydrofolate reductase gene polymorphisms and haplotype with toxicity response of high dose methotrexate chemotherapy].
Zhonghua Liu Xing Bing Xue Za Zhi
July 2012
Nanjing Children's Hospital, Nanjing Medical University, Nanjing 210008, China.
Objective: To investigate the association between single nucleotide polymorphisms (SNP) and its haplotypes of methylenetetrahydrofolate reductase (MTHFR) gene with high dose methotrexate (HDMTX)-induced toxicity in children with acute lymphoblastic leukemia (ALL).
Methods: HDMTX-treated children with ALL (1.2 to 14-years old) were selected from inpatient and followed for a retrospective study.
Monotherapy with methotrexate for primary central nervous lymphoma has single agent activity in the absence of radiotherapy: a single institution cohort.
J Neurooncol
July 2010
Duke University School of Medicine, 200 Trent Drive, Durham, NC 27710, USA.
We have retrospectively reviewed toxicities and response of a cohort of primary central nervous system lymphoma (PCNSL) patients treated with high dose parenteral methotrexate (MTX) monotherapy without whole brain radiation. From The Massachusetts General Hospital (MGH) Cancer Registry, active since 1946, we selected all immunocompetent patients with histologic and/or radiographic PCNSL diagnosed between 1980 and 2007. We identified the recipients of MTX with leucovorin rescue as sole therapy.
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