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Thoracic paraspinal muscle concentric needle electrode jitter analysis in electrophysiological diagnosis of ALS.
J Electromyogr Kinesiol
January 2025
Hacettepe University, Faculty of Medicine, Department of Neurology, Ankara, Turkey.
Objectives: Jitter analysis with concentric needle electrode of the thoracic 9 (T9) paraspinal muscle (PM), where the needle EMG examination at rest is difficult, was performed in both amyotrophic lateral sclerosis (ALS) patients and the controls.
Methods: For the T9 PM, both upper limit for mean and individual mean consecutive difference (MCD) values and spike numbers were calculated according to jitter values of pairs from controls. In addition to the descriptive statistics, differences between two groups and T9 PM needle EMG and jitter analysis findings of patients were compared (p = 0.
Neurophysiologic Innovations in ALS: Enhancing Diagnosis, Monitoring, and Treatment Evaluation.
Brain Sci
December 2024
Djavad Mowafaghian Centre for Brain Health, Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Amyotrophic lateral sclerosis (ALS) is a progressive disease of both upper motor neurons (UMNs) and lower motor neurons (LMNs) leading invariably to decline in motor function. The clinical exam is foundational to the diagnosis of the disease, and ordinal severity scales are used to track its progression. However, the lack of objective biomarkers of disease classification and progression delay clinical trial enrollment, muddle inclusion criteria, and limit accurate assessment of drug efficacy.
View Article and Find Full Text PDFPtosis in human immunodeficiency virus-infected patients under long-term antiretroviral treatment.
Clin Neurol Neurosurg
December 2024
Department of Neurosciences and Mental Health, Unidade Local de Saúde de Santa Maria, Lisbon, Portugal; Faculdade de Medicina-Instituto de Medicina Molecular, Centro de Estudos Egas Moniz, Universidade de Lisboa, Lisbon, Portugal.
Objective: To present cases of ptosis in HIV-1 patients on long-term antiretroviral therapy (ART) and review the existing literature.
Methods: Five HIV-1-positive patients with slowly progressive bilateral ptosis underwent a comprehensive diagnostic evaluation, including imaging studies, neurophysiological testing, muscle biopsy, and genetic analysis. A literature review was conducted.
Neuromuscular transmission deficits in patients with CMT and ClC-1 inhibition in CMT animal models.
Ann Clin Transl Neurol
December 2024
NextGen Precision Health, University of Missouri, Columbia, Missouri, USA.
Article Synopsis
- The study investigates neuromuscular junction (NMJ) function in patients with Charcot-Marie Tooth (CMT) disease and explores the potential for improving muscle strength through ClC-1 channel inhibition.
- Results showed significant NMJ abnormalities in CMT patients, such as increased jitter and blocking, which correlated with weaker muscle performance and endurance.
- Preclinical experiments indicated that a new drug, NMD670, improved muscle strength and endurance in CMT mice, suggesting that targeting NMJ dysfunction might offer a new therapeutic approach for CMT patients.
Relationship between fatigue and quantitative electromyography findings in patients with myasthenia gravis.
Heliyon
October 2024
Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Department of Neurology, Istanbul, Turkey.
Article Synopsis
- - The study examined muscle changes in myasthenia gravis (MG) patients experiencing fatigue, using quantitative electromyography (QEMG) and assessing their fatigue and disease severity through various measures.
- - Results indicated that MG patients with fatigue had distinct muscle electromagnetic patterns, including shorter and smaller muscle unit potentials, and these patterns were linked to higher fatigue levels and reduced muscle strength.
- - The findings suggest that muscle morphology in MG patients correlates with fatigue severity, paving the way for potential new insights into understanding and treating fatigue in these patients.
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