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Obtura: A novel liquid embolic agent with post-embolization radiopacity loss, in endovascular treatment of brain arteriovenous malformations, dural arteriovenous fistulas, and tumors: CLARIDAD trial.
J Neurointerv Surg
July 2024
JJ Merland Department of Therapeutic Neuroangiography of Hospital Universitari General de Catalunya, Hospital del Mar, Barcelona, Spain.
Background: Endovascular embolization is frequently used for vascular lesions of the head and neck. Newer agents may help to enhance visualization and improve treatment outcomes.
Methods: The CLARIDAD clinical trial was a prospective, single center, first-in-man investigation of neurovascular embolization using the novel embolic agent Obtura for a broad indication, covering the need for a liquid embolic agent in head and neck procedures.
Optical frequency domain imaging (OFDI) represents a novel technique for the diagnosis of giant cell arteritis.
Eye (Lond)
November 2024
Sussex Eye Hospital, University Hospitals Sussex NHS Foundation Trust, Eastern Road, BN2 5BF, Brighton, UK.
Background/objectives: Giant cell arteritis (GCA) is an inflammatory vascular disease in which prompt and accurate diagnosis is critical. The efficacy of temporal artery biopsy (TAB) is limited by 'skip' lesions and a delay in histological analysis. This first-in-man ex-vivo study aims to assess the accuracy of optical frequency domain imaging (OFDI) in diagnosing GCA.
View Article and Find Full Text PDFFirst-in-man study of the PSMA Minibody IR800-IAB2M for molecularly targeted intraoperative fluorescence guidance during radical prostatectomy.
Eur J Nucl Med Mol Imaging
August 2024
Department of Oncology, University of Oxford, Oxford, UK.
Article Synopsis
- Researchers tested a humanised PSMA minibody (IAB2M) linked to a fluorescent dye (IRDye 800CW) for imaging prostate cancer during robot-assisted surgeries.
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Autologous bone marrow derived mesenchymal stem cells are safe for the treatment of Achilles tendinopathy.
Sci Rep
May 2024
Department of Veterinary Clinical Sciences and Services, The Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire, AL9 7TA, UK.
Achilles tendinopathy is a disabling condition that affects more than 50% of runners. Pre-clinical studies in a large animal model of naturally-occurring tendinopathy similar to human Achilles tendinopathy has shown benefits of autologous bone marrow-derived mesenchymal stem cell (MSC) implantation. However, MSCs are advanced therapies medicinal products (ATMPs), with strict regulatory requirements.
View Article and Find Full Text PDFFirst in man: blocking the false lumen backflow of aortic dissection after thoracic endovascular aortic repair by an off-the-shelf EndoSeal™ system.
Eur Heart J
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Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
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