AI Article Synopsis
- * Researchers analyzed genetic data from 475 patients with varicose veins, 168 healthy individuals, and a broader group of 896 subjects using various statistical models.
- * Findings revealed that neither polymorphism had a significant association with varicose vein risk, indicating they do not influence the genetic susceptibility in this population.
Article Abstract
Objectives: The objective of this study was to study the association of polymorphisms MTHFR C677T (rs1801133) and MTR A2756G (rs1805087) with the risk of varicose veins in ethnical Russians.
Methods: We genotyped 475 patients with varicose veins, 168 individual without chronic venous disease, and the population-based group of 896 subjects. Association was studied using logistic regression analysis adopting co-dominant, additive, recessive, and dominant models of inheritance.
Results: None of the polymorphisms showed a statistically significant association with the risk of varicose veins.
Conclusions: Our results provide evidence that the studied polymorphisms do not contribute to genetic susceptibility to varicose veins in ethnical Russians.
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| http://dx.doi.org/10.3109/1354750X.2016.1171902 | DOI Listing |
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