Escalating pain is common in the final weeks of life, requiring skilled management to assist patients with a life-limiting illness. Using a cancer model, pharmacologic approaches to treat pain in the final weeks of life are reviewed.
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| http://dx.doi.org/10.1097/01.NPR.0000482376.29488.79 | DOI Listing |
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Real-Life Experience with Tildrakizumab in Plaque Psoriasis with Palmoplantar Involvement: A Multi-Center Retrospective Italian Study.
Dermatol Ther (Heidelb)
January 2025
Department of Clinical and Molecular Sciences-Dermatological Clinic, Università Politecnica Delle Marche, Ancona, Italy.
Introduction: Palmoplantar psoriasis (PPp) has a profound negative impact on patients' quality of life, and it represents a therapeutic challenge, as palms and soles are difficult to treat area. Although the efficacy profile of tildrakizumab has been well evaluated in the literature, data on its use for PPp are still limited. The objective of the study was to evaluate the efficacy and safety of tildrakizumab on moderate-to-severe plaque psoriasis with involvement of the palmoplantar area.
View Article and Find Full Text PDFThe Ellipsoid Zone Is a Structural Biomarker for Visual Outcomes in Diabetic Macular Edema and Macular Hole Management.
Vision (Basel)
January 2025
Department of Ophthalmology, King George's Medical University, Lucknow 226003, India.
Objectives: The goal was to study the ellipsoid zone (EZ) as a structural biomarker for final visual outcomes after pharmacological intervention in center-involving diabetic macular edema (DME) and surgical intervention for full-thickness macular holes (FTMHs).
Methods: This was a tertiary care center-based retrospective study. After sample size calculations, data from 64 consecutive cases were collected, with subjects aged between 40 and 60 years.
Video-feedback intervention for promoting social engagement in children with neurodevelopmental disabilities.
Front Psychol
January 2025
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
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View Article and Find Full Text PDFSalivary testosterone and cortisol responses to seven weeks of practical blood flow restriction training in collegiate American football players.
Front Physiol
January 2025
Jayhawk Athletic Performance Laboratory - Wu Tsai Human Performance Alliance, University of Kansas, Lawrence, KS, United States.
Purpose: The purpose of this study was to examine the effects of a 7-week supplemental BFR training intervention on both acute and chronic alterations in salivary testosterone (sTes) and cortisol (sCort) in collegiate American football players.
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Effects of exercise training on nigrostriatal neuroprotection in Parkinson's disease: a systematic review.
Front Neurosci
January 2025
Department of Physical Therapy, China Medical University, Taichung, Taiwan.
Introduction: Parkinson's disease (PD) is characterized by progressive neurodegeneration within the nigrostriatum, leading to motor dysfunction. This systematic review aimed to summarize the effects of various exercise training regimens on protein or gene expression within the nigrostriatum and their role in neuroprotection and motor function improvement in animal models of Parkinson's disease (PD).
Methods: PubMed, EMBASE, and Web of Science were searched up to June 2024 and included sixteen studies that adhere to PRISMA guidelines and CAMARADES checklist scores ranging from 4 to 6 out of 10.
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