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Development and validation of animal variant classification guidelines to objectively evaluate genetic variant pathogenicity in domestic animals.
Front Vet Sci
December 2024
Laboratory of Animal Genetics, Department of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Assessing the pathogenicity of a disease-associated genetic variant in animals accurately is vital, both on a population and individual scale. At the population level, breeding decisions based on invalid DNA tests can lead to the incorrect inclusion or exclusion of animals and compromise the long-term health of a population, and at the level of the individual animal, lead to incorrect treatment and even life-ending decisions. Criteria to determine pathogenicity are not standardized, i.
View Article and Find Full Text PDFChallenging Conventional Wisdom: Early Treatment and Chronicity Outcomes in Acute Severe Hepatitis B.
Int J Med Sci
December 2024
Ankara Bilkent City Hospital, Department of Gastroenterology, Ankara, Turkey.
Article Synopsis
- * Out of 57 patients analyzed, significant clinical differences were observed between the treatment and untreated groups, but both groups had similar baseline demographic and laboratory characteristics.
- * The results indicated that while early antiviral therapy led to better short-term HBsAg seroclearance rates, it did not prevent chronic hepatitis B or significantly differ in key clinical outcomes, suggesting the need for further, larger randomized studies.
Restoration of forestry-drained boreal peatland ecosystems can effectively stop and reverse ecosystem degradation.
Commun Earth Environ
November 2024
Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland.
Ecosystem restoration will increase following the ambitious international targets, which calls for a rigorous evaluation of restoration effectiveness. Here, we present results from a long-term before-after control-impact experiment on the restoration of forestry-drained boreal peatland ecosystems. Our data comprise 151 sites, representing six ecosystem types.
View Article and Find Full Text PDFEffectiveness of platelet-rich fibrin in third molar extractions: a randomized controlled split-mouth study.
Clin Oral Investig
October 2024
Division of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria.
Objectives: To date, studies have only investigated the use of platelet-rich fibrin (PRF) after removal of third molars from the mandible or maxilla. Removal of the upper and lower third molars is typically combined into one session per side; therefore, this study aimed to investigate influence on PRF.
Materials And Methods: This prospective, single-blinded, randomized controlled, clinical trial (split-mouth design) included 25 patients.
Agents seeking long-term access to the wisdom of the crowd reduce immediate decision-making accuracy.
Philos Trans R Soc Lond B Biol Sci
December 2024
Department of Statistics, School of Mathematics, University of Leeds, Leeds LS2 9JT, UK.
Living in groups offers social animals the significant advantage of accessing collective wisdom and enhanced information processing, enabling more accurate decisions related to foraging, navigation and habitat selection. Preserving group membership is crucial for sustaining access to collective wisdom, incentivizing animals to prioritize group cohesion. However, when individuals encounter divergent information about the quality of various options, this can create a conflict between pursuing immediate rewards and the maintenance of group membership to improve access to future pay-offs.
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