Introduction: Obstructive sleep apnea (OSA) and its craniofacial anatomic risk factors might play a role in several cardiovascular diseases, including myocardial infarction (MI). However, there are no data about cephalometric findings among OSA patients with MI.
Methods: In this pilot case-control study, about 2000 individuals referred to the sleep center were evaluated according to apnea - hypopnea index (AHI) and other inclusion criteria. Included were 62 OSA male patients (AHI > 10), of whom 6 had an MI history. In both control (n = 56) and MI groups (n = 6), 18 cephalometric parameters were traced. Data were analyzed using independent samples t-test.
Results: Compared with control OSA patients, OSA patients with MI showed a significantly larger tongue length (p = 0.015). The other cephalometric variables were not significantly different between the two groups.
Conclusion: An elongated tongue might be considered a risk factor for MI in OSA patients. The role of other variables remains inconclusive and open to investigation with larger samples (determined based on pilot studies such as this report) collected in longitudinal fashion.
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http://dx.doi.org/10.1080/08869634.2016.1169615 | DOI Listing |
Int Clin Psychopharmacol
January 2025
Department of Medicine, University of California, San Francisco - Fresno, Fresno, California, USA.
Obstructive sleep apnea (OSA) is a prevalent sleep disorder linked to significant daytime sleepiness and mood disturbances. Continuous positive airway pressure (CPAP) therapy is the standard treatment for OSA, but its effects on mental health outcomes, are not well understood. This study aimed to evaluate the impact of CPAP on daytime sleepiness, depressive symptoms, and anxiety symptoms while assessing how improvements vary with age.
View Article and Find Full Text PDFBackground: Obstructive sleep apnea (OSA) is a complex and heterogeneous condition associated with chronic physiological and neuropsychological disturbances (1-4). One notable neuropsychological effect observed in OSA patients is memory impairment (2,5). Additionally, some reports suggest that OSA may be associated with Alzheimer's Disease (AD) (4).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Hospital Universitari Santa Maria de Lleida, IRBLleida, Lleida, Spain.
Background: Obstructive sleep apnoea (OSA) is the sleep disorder most frequently found in patients with Alzheimer's disease (AD). The intermittent hypoxia (IH) caused by OSA may participate in AD pathogenesis through increase in oxidative damage and inflammation. We aimed to identify inflammatory and redox genes differentially expressed in the blood from AD patients with severe OSA compared with those with nonsevere OSA.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Miami Miller School of Medicine, Miami, FL, USA.
Background: T/S ratio represents the average telomere length per genome, and has been previously linked to Alzheimer's Disease (AD) and biological sex [1], but there is a gap in our understanding of its interactions with sleep patterns. Towards filling this gap, we present a preliminary analysis exploring correlations between age, biological sex, T/S ratio and presence of a sleep disorder for patients with mild cognitive impairment (MCI) and AD against a "cognitively normal" (NL) baseline.
Method: Expanding on our previous work [2] we include the T/S ratio and the biological sex variables from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset (n = 1409).
Alzheimers Dement
December 2024
Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.
Background: Sleep-related breathing disorders are commonly reported in the Down Syndrome (DS) population, but data on its prevalence and severity are scarce, especially for the adult population. The increase in life expectancy and premature aging in patients with DS reinforces the need for an assessment of sleep quality. This study evaluated sleep-disordered breathing in adults with DS using sleep measures by polysomnography.
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