AI Article Synopsis
- The study aimed to investigate how serum BDNF levels change after a combined treatment for postherpetic neuralgia (PHN).
- A group of 60 patients was divided into two: one receiving pregabalin with pulsed radiofrequency and the other receiving pregabalin with a sham treatment.
- Results showed that pain decreased faster in the treatment group, and both groups experienced an increase in serum BDNF levels, with the treatment group showing a more significant rise.
Article Abstract
Aim: To study the modulation of serum BDNF levels following integrated multimodal intervention in postherpetic neuralgia (PHN).
Materials & Methods: A randomized, double-blind controlled study was undertaken among patients of thoracic PHN where 30 patients received pregabalin with pulsed radiofrequency and 30 controls received pregabalin with sham treatment.
Results: Pain intensity (visual analog scale) was reduced earlier in intervention group (15.3 ± 5.7 at the fourth week) compared with control group (16.3 ± 6.6 at the eighth week). Serum BDNF level increased with time in both the groups with overall increase more pronounced in intervention group.
Conclusion: Integrated multimodal therapy using minimally invasive pulsed radiofrequency and pregabalin in PHN was effective in early pain reduction with elevated serum BDNF levels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/pmt.16.3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!