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Clinical Courses of Two Pediatric Patients with Acute Megakaryoblastic Leukemia Harboring the CBFA2T3-GLIS2 Fusion Gene. | LitMetric

AI Article Synopsis

  • Acute megakaryoblastic leukemia (AMKL) in children without Down syndrome has a low 3-year survival rate of under 40%, whereas those with Down syndrome achieve much better outcomes.
  • A new genetic translocation involving the CBFA2T3 and GLIS2 genes is found in about 30% of non-DS AMKL cases, and this fusion gene indicates a worse prognosis for affected children.
  • The article discusses the challenging clinical experiences of pediatric patients diagnosed with AMKL who carry the CBFA2T3-GLIS2 fusion gene.

Article Abstract

Acute megakaryoblastic leukemia (AMKL) in children without Down syndrome (DS) has an extremely poor outcome with 3-year survival of less than 40%, whereas AMKL in children with DS has an excellent survival rate. Recently, a novel recurrent translocation involving CBFA2T3 and GLIS2 was identified in about 30% of children with non-DS AMKL, and the fusion gene was reported as a strong poor prognostic factor in pediatric AMKL. We report the difficult clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204189PMC
http://dx.doi.org/10.4274/tjh.2016.0008DOI Listing

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