AI Article Synopsis
- Pterin deaminase is an enzyme that breaks down pteridines to produce lumazine derivatives and ammonia, with potential use as an anticancer agent.
- Though the enzyme has been studied since 1959 and is found in various organisms, its exact role in eukaryotes remains unclear.
- This review aims to highlight the importance of pterin deaminase and identify gaps in knowledge regarding its structure and function.
Article Abstract
Pterin deaminase is an amidohydrolase enzyme hydrolyzing pteridines to form lumazine derivatives and ammonia. The enzyme captured the attention of scientists as early as 1959 and had been patented for its application as an anticancer agent. It is ubiquitously present in prokaryotes and has been reported in some eukaryotes such as honey bee, silkworm and rats. The enzyme has been observed to have a spectrum of substrates with the formation of respective lumazines. The role of the substrates of the enzyme in various metabolic pathways warrants a significant role in the biological activity of both prokaryotes and eukaryotes. Even though the functions of the enzyme have been explored in prokaryotes, their niche in the eukaryotic system is not clear. There is very few information on the structural and functional properties of the enzyme. This review has been congregated to emphasize the significance of pterin deaminase and analyzes the lacunae in understanding the biological characters of the enzyme.
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| http://dx.doi.org/10.1007/s00253-016-7513-9 | DOI Listing |
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