AI Article Synopsis
- Centromeres in higher eukaryotes are marked by a specific nucleosome containing the CENP-A histone variant, which is inherited epigenetically.
- Researchers Rosin and Mellone (2016) explored how the CENP-A variant and its chaperone CAL1 evolved together.
- Their study highlights that the co-evolution of these proteins leads to incompatibility in centromeric histones among different species of Drosophila.
Article Abstract
Centromeres of higher eukaryotes are defined by the epigenetic inheritance of the centromere-specific CENP-A nucleosome. Reporting in Developmental Cell, Rosin and Mellone (2016) show that co-evolution of the CENP-A histone variant and its chaperone CAL1 accounts for species incompatibility between centromeric histones in Drosophila.
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| http://dx.doi.org/10.1016/j.devcel.2016.04.006 | DOI Listing |
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